Objective Leishmania causes devastating human diseases – leishmaniases - representing an important public health problem in the Mediterranean basin and declared as emerging diseases in the EU due to climate change and population displacement. The LeiSHield-MATI consortium will for the first time investigate in an integrative fashion the complex parasite-vector-host interplay in cutaneous leishmaniasis affecting Morrocco, Algeria, Tunisia, and Iran (MATI), using field isolates and human clinical samples. The ultimate goal of our project is to identify genetic factors selected during natural infection and to understand how the complex parasite-vector-animal interaction impacts clinical outcome in infected patients. This goal will be achieved through a highly ambitious secondment plan between all partners, and the organization of courses and workshops to train the next generation of scientists generating a long-term impact on the research capacities in endemic areas. Capitalizing on complementary infrastructures of its EU, African and Asian partners and their expertise in molecular parasitology, epidemiology, systems level analyses, bioinformatics, computational biology, immunology, dermatology, field studies, and public health, our project will drive important innovation in clinical research, strengthen capacities in disease endemic regions, inform authorities on control measures, and raise awareness in all partner countries on this emerging EU public health problem. The highly inter-disciplinary and inter-sectorial structure of LeiSHield-MATI, and its powerful integrative and comparative approach is novel in parasitic systems and will drive a unique bio-marker discovery pipeline for the future development of new prognostic and diagnostic tools, as well as novel preventive and therapeutic measures that will ensure long-term collaboration, promote scientific and commercial self-sustainability of its partners, and will have an important impact to improve public health. Fields of science medical and health sciencesclinical medicinedermatologymedical and health scienceshealth sciencespublic healthepidemiologymedical and health scienceshealth sciencesparasitologymedical and health sciencesbasic medicineimmunologynatural sciencesearth and related environmental sciencesatmospheric sciencesclimatologyclimatic changes Keywords Leishmanioses parasite-vector-host interaction RNAseq HTseq biomarkers prognostic and diagnostic tools CL psychological impact immune response Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge Topic(s) MSCA-RISE-2017 - Research and Innovation Staff Exchange Call for proposal H2020-MSCA-RISE-2017 See other projects for this call Funding Scheme MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Coordinator INSTITUT PASTEUR Net EU contribution € 544 500,00 Address RUE DU DOCTEUR ROUX 25-28 75724 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 544 500,00 Participants (7) Sort alphabetically Sort by Net EU contribution Expand all Collapse all INSTITUUT VOOR TROPISCHE GENEESKUNDE Belgium Net EU contribution € 63 000,00 Address NATIONALESTRAAT 155 2000 ANTWERPEN See on map Region Vlaams Gewest Prov. Antwerpen Arr. Antwerpen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 63 000,00 ACOBIOM France Net EU contribution € 13 500,00 Address 1682 RUE DE LA VALSIERE CAP DELTA ZAC EUROMEDECINE II 34790 Grabels See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Occitanie Languedoc-Roussillon Hérault Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 13 500,00 INSTITUT PASTEUR DE TUNIS Tunisia Net EU contribution € 756 000,00 Address Place Pasteur 13 1002 Tunis See on map Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 756 000,00 UNIVERZITA KARLOVA Czechia Net EU contribution € 94 500,00 Address OVOCNY TRH 560/5 116 36 Praha 1 See on map Region Česko Praha Hlavní město Praha Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 94 500,00 GOETEBORGS UNIVERSITET Sweden Net EU contribution € 148 500,00 Address VASAPARKEN 405 30 Goeteborg See on map Region Södra Sverige Västsverige Västra Götalands län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 148 500,00 INSTITUT DE RECHERCHE POUR LE DEVELOPPEMENT France Net EU contribution € 121 500,00 Address BOULEVARD DE DUNKERQUE 44 CS 90009 13572 Marseille See on map Region Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 121 500,00 COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES France Net EU contribution € 9 000,00 Address RUE LEBLANC 25 75015 PARIS 15 See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 9 000,00 Partners (3) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. INSTITUT PASTEUR D'IRAN Iran Net EU contribution € 0,00 Address PASTEUR AVE 69 1316943551 TEHRAN See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 504 000,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. Institut Pasteur Du Maroc Morocco Net EU contribution € 0,00 Address Place Louis Pasteur 1 20360 Casablanca See on map Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 288 000,00 Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. INSTITUT PASTEUR D ALGERIE E.P.I.C. Algeria Net EU contribution € 0,00 Address ROUTE DU PETIT STAOUELI DELY BRAHIM 16000 Alger See on map Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 436 500,00
