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Selective Hydrogenation of Arenes - A Dream Reaction

Project information

Grant agreement ID: 788558

Status

Ongoing project

  • Start date

    1 October 2018

  • End date

    30 September 2023

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 2 495 000

  • EU contribution

    € 2 495 000

Hosted by:

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Germany

Objective

The hydrogenation of ketones and olefins is one of the oldest synthetically used transformations. The reaction is highly sustainable and its value has been acknowledged by two Nobel Prizes. In contrast, the hydrogenation of arenes is still underexplored due to the high kinetic barrier caused by aromaticity. However, the selective arene hydrogenation constitutes a dream reaction for use in an ideal synthesis: The transformation is straightforward, uses readily available substrates, and is able to build-up an astonishing amount of complexity, with the potential to form multiple defined sterocentres, in a single step. With our first paper on selective arene hydrogenation published in 2004, we became pioneers in this field and have continuously made important contributions using metal–carbene complexes. As a world-leader in this area and with expertise in several relevant fields of catalysis, we are perfectly suited to convert arene hydrogenation into a reliable and general transformation within the frame of this project. We will provide rapid access to sought-after motifs and consequently will enable breakthroughs in material and life sciences.

Key to our success will be the design of strongly electron-donating carbene ligands and deep mechanistic understanding. Specifically, we will develop solutions for the problematic hydrogenation of heteroatom-substituted arenes, and heteroarenes. Utilising the soluble nature of a homogenous catalyst, we also envision applications in the hydrogenation of polymers, offering direct access to new materials. Furthermore, the use of syngas is expected to allow for the development of a merged hydrogenation-hydroformylation reaction to yield highly functionalised cyclohexanes in a single step from minimally functionalised arenes. Finally, we aim to develop chiral versions of our highly reactive metal–carbene catalyst to enable the previously unknown but highly desirable enantioselective hydrogenation of benzene derivatives.
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Host institution

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Address

Schlossplatz 2
48149 Muenster

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 2 495 000

Beneficiaries (1)

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Germany

EU Contribution

€ 2 495 000

Project information

Grant agreement ID: 788558

Status

Ongoing project

  • Start date

    1 October 2018

  • End date

    30 September 2023

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 2 495 000

  • EU contribution

    € 2 495 000

Hosted by:

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Germany