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Elaboration of the type I interferonopathies

Elaboration of the type I interferonopathies

Objective

Type I interferons represent both key molecules in anti-viral defence and mediators of inflammatory disease, so that the induction, transmission and resolution of the interferon response are tightly regulated - balancing protection against infection versus the risk of immunopathology. Monogenic type I interferonopathies (T1IFNs), and related ‘complex’ phenotypes such as systemic lupus erythematosus and dermatomyositis, represent examples of a disturbance of the homeostatic control of this system, where a constitutive upregulation of type I interferon activity is considered directly relevant to pathology.

Set against the absence of a routine assay in clinical medicine for the detection of upregulated type I interferon, the current application addresses major questions in the developing T1IFN field. Analogous to other screening strategies (e.g. using mouse ENU mutagenesis or yeast gene deletion series), we have established a pipeline for the systematic identification of human mutant states predisposing to upregulated type I interferon signalling. Such an approach will allow for the comprehensive definition of important themes in interferon biology, informing our understanding of anti-viral signalling and self-non-self discrimination. Furthermore, these studies will have direct translational benefit - since the identification of a phenotype as a T1IFN implies the possibility of therapy to reduce type I interferon levels and / or block interferon signalling.
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Host institution

THE UNIVERSITY OF EDINBURGH

Address

Old College, South Bridge
Eh8 9yl Edinburgh

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 2 418 800

Beneficiaries (1)

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THE UNIVERSITY OF EDINBURGH

United Kingdom

EU Contribution

€ 2 418 800

Project information

Grant agreement ID: 786142

Status

Ongoing project

  • Start date

    1 November 2018

  • End date

    31 October 2023

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 2 418 800

  • EU contribution

    € 2 418 800

Hosted by:

THE UNIVERSITY OF EDINBURGH

United Kingdom