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Building the product pipeline for commercial demonstration of Plant Molecular Factories

Objective

Plant Molecular Farming is the manufacture of high-value products using plant biotechnology. Pharma-Factory was conceived and designed by SMEs active in the field to produce medical, veterinary and diagnostic products. Product-driven work packages and a collective approach to public involvement and regulatory consultation will accelerate commercialisation of new bio-products, and increase the competitiveness of European bio-industry by resolving technical, social and economic bottlenecks in this field. All parts of the work programme are addressed by refining technologies using new synthetic biology tools, demonstrating manufacturing advantages for individual products, identifying a clear regulatory path for each platform technology, developing clear business cases with supporting techno-economic evaluations and life cycle analyses and improving public engagement and acceptance. Five SMEs will develop products that include arylsulfatase B (for human enzyme replacement therapy), a vaccine for infectious spleen and kidney necrosis virus in fish, two highly potent HIV neutralising antibody-based fusion proteins and plant chimaeric virus-like-particles for a diagnostic kit. In collaboration with academic partners they will advance six plant molecular farming platforms for this purpose, including whole plants, algae, hairy roots and plant cell culture, by designing and developing new tools to increase the competitiveness, utility and versatility of each platform. All companies will reach Technology Readiness Level 5 within the lifetime of the project, with two products to be commercialized. The project provides a unique opportunity to improve public involvement with plant biotechnology at a European-wide level. A work package has been dedicated to gain maximal impact by engaging with all stakeholders – from scientists to government and the public at large, developing new tools to facilitate communication, to help understand and reduce barriers to acceptance.

Call for proposal

H2020-BB-2016-2017

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Sub call

H2020-BB-2017-1

Coordinator

ST GEORGE'S HOSPITAL MEDICAL SCHOOL
Net EU contribution
€ 1 616 093,30
Address
Cranmer Terrace
SW17 0RE London
United Kingdom

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Region
London Inner London — West Wandsworth
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,25

Participants (13)

DIAMANTE SRL
Italy
Net EU contribution
€ 499 625,00
Address
Strada Le Grazie 15
37134 Verona

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Nord-Est Veneto Verona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 214 125,00
UNIVERSITE DE ROUEN NORMANDIE
France
Net EU contribution
€ 531 500,00
Address
Rue Thomas Becket 1 Mont Saint Aignan
76821 Mont Saint Aignan Cedex

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Region
Normandie Haute-Normandie Seine-Maritime
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ALBAJUNA THERAPEUTICS
Spain
Net EU contribution
€ 400 312,50
Address
Ctra Del Canyet, S/n, Hospital Germans Trias I Pujol, 2 Planta
08916 Badalona

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Este Cataluña Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 171 562,50
LEAF SYSTEMS INTERNATIONAL LIMITED
United Kingdom
Net EU contribution
€ 384 040,13
Address
Building 7, Zone 2, Norwich Research Park, Colney Lane, Colney
NR47UJ Norwich

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Region
East of England East Anglia Norwich and East Norfolk
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 164 588,62
TRANSALGAE ISRAEL LTD
Israel
Net EU contribution
€ 519 750,00
Address
2 Haim Pekeris Street
7670202 Tehovot

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 222 750,00
UNIVERSIDAD DE LLEIDA
Spain
Net EU contribution
€ 519 902,50
Address
Placa Victor Siurana 1 1
25003 Lleida

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Region
Este Cataluña Lleida
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
SAMABRIVA
France
Net EU contribution
€ 455 700,00
Address
72 Rue Des Jacobins
80000 Amiens

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Region
Hauts-de-France Picardie Somme
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 195 300,00
JOHN INNES CENTRE
United Kingdom
Net EU contribution
€ 509 982,50
Address
Norwich Research Park Colney
NR4 7UH Norwich

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Region
East of England East Anglia Breckland and South Norfolk
Activity type
Research Organisations
Non-EU contribution
€ 0,00
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
Net EU contribution
€ 519 710,00
Address
Calle Serrano 117
28006 Madrid

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Region
Comunidad de Madrid Comunidad de Madrid Madrid
Activity type
Research Organisations
Non-EU contribution
€ 0,00
THE UNIVERSITY OF THE ARTS LONDON
United Kingdom
Net EU contribution
€ 619 791,45
Address
272 High Holburn
WC1V 7EY London

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Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITY COLLEGE LONDON
United Kingdom
Net EU contribution
€ 524 226,25
Address
Gower Street
WC1E 6BT London

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Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
TEKNOLOGIAN TUTKIMUSKESKUS VTT OY
Finland
Net EU contribution
€ 560 827,50
Address
Tekniikantie 21
02150 Espoo

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Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Research Organisations
Non-EU contribution
€ 0,00
FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany
Net EU contribution
€ 624 547,50
Address
Hansastrasse 27c
80686 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Non-EU contribution
€ 0,00