CORDIS
EU research results

CORDIS

English EN
Targeting neuroinflammation to combat pathological pain in neurodegenerative diseases and chronic pain syndromes

Targeting neuroinflammation to combat pathological pain in neurodegenerative diseases and chronic pain syndromes

Objective

Damage to the central (CNS) and peripheral (PNS) nervous systems causes altered perception of pain (pathological pain) which is a common feature of diseases that have high prevalence in the European Union. Both increases and decreases in the ability to perceive pain impair both performance at work and quality of life. Pathological pain in neurodegenerative diseases, musculoskeletal diseases and peripheral neuropathies is associated with neuroinflammation, the inflammatory process whereby non-neuronal (inflammatory and glia) cells interact with neurones by releasing molecules that modulate pain signalling. TOBeATPAIN suggest that neuroinflammation represents an underlying mechanism of pathological pain states encompassing those with a PNS or CNS origin. The focus of this ITN will be on the mechanisms by which non-neuronal cells impact on neuronal activity in order to identify innovative non-neuronal targets for the treatment of pathological pain in peripheral macrophages or CNS microglia/astrocytes. TOBeATPAIN delivers high-level scientific and innovation-oriented complementary training, forging career pathways to increase inter-sectorial and transnational employability of young entrepreneurially-minded scientists in the academic and industrial sectors. It combines the expertise of 5 leading academic institutions, 2 pharmaceutical companies and 1 SME as Beneficiaries, together with 2 SMEs and 1 non-profit research charity as Partner Organisations, from 4 European countries. Fully aligned with the ‘Knowledge Triangle’ (business, research, higher education) platform, eleven ESRs will gain valuable knowledge and multidisciplinary skills through interdisciplinary research projects that integrate state-of-the-art technologies, supervision by and secondments to industrial Network organisations, Network-wide and local training activities, and specialized transferable skills focused in the acquisition of the ‘3-Knowledges’ (K-creation, K-exploitation, K-communication).
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

KING'S COLLEGE LONDON

Address

Strand
Wc2r 2ls London

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 546 575,76

Participants (7)

Sort alphabetically

Sort by EU Contribution

Expand all

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 527 318,64

MEDIZINISCHE UNIVERSITAT INNSBRUCK

Austria

EU Contribution

€ 255 934,08

Universitätsklinikum Jena

Germany

EU Contribution

€ 498 432,96

UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT

Germany

EU Contribution

€ 249 216,48

KANCERA AB

Sweden

EU Contribution

€ 263 659,32

BIONORICA RESEARCH GMBH

Austria

EU Contribution

€ 255 934,08

Eli Lilly and Company Limited

United Kingdom

EU Contribution

€ 273 287,88

Project information

Grant agreement ID: 764860

Status

Ongoing project

  • Start date

    1 August 2018

  • End date

    31 July 2022

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 2 870 359,20

  • EU contribution

    € 2 870 359,20

Coordinated by:

KING'S COLLEGE LONDON

United Kingdom