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Targeting neuroinflammation to combat pathological pain in neurodegenerative diseases and chronic pain syndromes

Objective

Damage to the central (CNS) and peripheral (PNS) nervous systems causes altered perception of pain (pathological pain) which is a common feature of diseases that have high prevalence in the European Union. Both increases and decreases in the ability to perceive pain impair both performance at work and quality of life. Pathological pain in neurodegenerative diseases, musculoskeletal diseases and peripheral neuropathies is associated with neuroinflammation, the inflammatory process whereby non-neuronal (inflammatory and glia) cells interact with neurones by releasing molecules that modulate pain signalling. TOBeATPAIN suggest that neuroinflammation represents an underlying mechanism of pathological pain states encompassing those with a PNS or CNS origin. The focus of this ITN will be on the mechanisms by which non-neuronal cells impact on neuronal activity in order to identify innovative non-neuronal targets for the treatment of pathological pain in peripheral macrophages or CNS microglia/astrocytes. TOBeATPAIN delivers high-level scientific and innovation-oriented complementary training, forging career pathways to increase inter-sectorial and transnational employability of young entrepreneurially-minded scientists in the academic and industrial sectors. It combines the expertise of 5 leading academic institutions, 2 pharmaceutical companies and 1 SME as Beneficiaries, together with 2 SMEs and 1 non-profit research charity as Partner Organisations, from 4 European countries. Fully aligned with the ‘Knowledge Triangle’ (business, research, higher education) platform, eleven ESRs will gain valuable knowledge and multidisciplinary skills through interdisciplinary research projects that integrate state-of-the-art technologies, supervision by and secondments to industrial Network organisations, Network-wide and local training activities, and specialized transferable skills focused in the acquisition of the ‘3-Knowledges’ (K-creation, K-exploitation, K-communication).

Coordinator

KING'S COLLEGE LONDON
Net EU contribution
€ 728 767,68
Address
Strand
WC2R 2LS London
United Kingdom

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Other funding
€ 728 767,68

Participants (7)

KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 527 318,64
Address
Nobels Vag 5
17177 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Other funding
€ 527 318,64
MEDIZINISCHE UNIVERSITAT INNSBRUCK
Austria
Net EU contribution
€ 255 934,08
Address
Christoph Probst Platz 1
6020 Innsbruck

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Region
Westösterreich Tirol Innsbruck
Activity type
Higher or Secondary Education Establishments
Other funding
€ 255 934,08
UNIVERSITATSKLINIKUM JENA
Germany
Net EU contribution
€ 498 432,96
Address
Kastanienstr.1
07747 Jena

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Region
Thüringen Thüringen Jena, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 498 432,96
UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT
Germany
Net EU contribution
€ 249 216,48
Address
Josef-schneider-strasse 2
97080 Wurzburg

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Region
Bayern Unterfranken Würzburg, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Other funding
€ 249 216,48
KANCERA AB
Sweden
Net EU contribution
€ 263 659,32
Address
Banvaktsvagen 22 Karolinska Institutet Science Park
171 48 Solna

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Östra Sverige Stockholm Stockholms län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 263 659,32
BIONORICA RESEARCH GMBH
Austria
Net EU contribution
€ 255 934,08
Address
Mitterweg 24
6020 Innsbruck

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Region
Westösterreich Tirol Innsbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 255 934,08
ELI LILLY AND COMPANY LTD

Participation ended

United Kingdom
Net EU contribution
€ 91 095,96
Address
Lilly House Basingview
RG21 4FA Basingstoke
Region
South East (England) Hampshire and Isle of Wight North Hampshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 91 095,96