Objective Proposed to break new ground quickly and to establish new frontiers in cutting-edge Csp3-H functionalization chemistry, this proposal focuses on the development and exploitation of iron catalysed carbene transfer towards saturated hydrocarbons, a vast and low cost feedstock for the synthesis of more valuable chemicals. By rational design and evaluation of low toxicity and low cost iron complexes equipped with different electronic and steric properties, new environmental benign and sustainable catalytic strategies will be instilled into this promising synthetic methodology. Extending beyond the confines of traditional precious metals catalysed carbene transference, new non-hazardous sources for these fragments, compared with the currently employed diazocompounds, will be designed and refined in sulfur ylide compounds and zinc carbenoid reagents. The project will benefit from the accumulated wealth of experience of the candidate Dr. Hernán-Gómez in synthesis, characterization and kinetic studies of highly reactive organometallic reagents, spanning from transition metals to main group elements. This will offer valuable mechanistic insights into the investigated processes, including unequivocal identification of the catalytic active species, key aspects to progress the proposed project. Additionally, through collaboration with supervisor Prof. Costas, an internationally recognised leader in the chemistry of iron compounds applied to organic synthesis, Dr. Hernán-Gómez will be provided with the required support to successfully push forwards the frontiers of the proposed research line in the field of iron chemistry, a stepping stone towards achieving a senior academic position. Fields of science natural scienceschemical sciencesinorganic chemistryalkali metalsnatural scienceschemical sciencesinorganic chemistryorganometallic chemistrynatural scienceschemical sciencesinorganic chemistrytransition metalsnatural sciencesphysical sciencesopticsspectroscopyabsorption spectroscopynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Keywords Iron Chemistry Carbenes Alkanes functionalization Catalysis Kinetics X-ray characterization Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2017 - Individual Fellowships Call for proposal H2020-MSCA-IF-2017 See other projects for this call Funding Scheme MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Coordinator UNIVERSITAT DE GIRONA Net EU contribution € 170 121,60 Address PLACA SANT DOMENEC 3 17004 Girona Spain See on map Region Este Cataluña Girona Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 170 121,60