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iFERMENTER - CONVERSION OF FORESTRY SUGAR RESIDUAL STREAMS TO ANTIMICROBIAL PROTEINS BY INTELLIGENT FERMENTATION

Objective

Plant dry matter, so-called lignocellulosic biomass, is the largest renewable biomass feedstock on Earth. Europe has over 14 mill tons of sugar residuals from biorefineries, which could be converted to profitable products and contribute to a sustainable bioeconomy. Unfortunately, existing biorefineries struggle with technical issues and low profitability due to the lack of adequate fermentation processes. Therefore, these sugars are either incinerated to generate energy or at best converted to ethanol (€0.6 /kg) but not to higher value chemicals.
Current concepts that aim to establish fermentation processes to convert residual sugar streams to high value products face challenges including inefficient sugar utilization by microorganisms and inhibitors in the residual streams, leading to low productivity and yields.
Our project aims to recover high value compounds from sugar residuals, and to turn fermentation processes converting these residual to antimicrobials cost effective. We will recover the high value sugar galactose (€40-200 /kg) from residual streams as part of their treatment process. By genome editing technique, we will design cell factories that consume the remaining residuals and produce nisin (€50-150 /kg), an industrially important commercial food/feed preservative. Additionally, we will develop an affordable, online feedback add-on system that will allow to intelligently change residual mixture during fermentation of these cell factories to optimize production online during the process. In a 150 L industrial bioreactor, we will demonstrate that our add-on invention iFermenter
- increases the yields of nisin by over 2 fold
- increases the nisin production by over 50% compared to what is possible today,
- and reduce at least 20% in CO2 footprint with this process compared to existing solutions.
Thus, iFermenter will render production of high value products with residual sugar stream highly efficient and cost-effective contributing to circular economy.
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Coordinator

NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU

Address

Hogskoleringen 1
7491 Trondheim

Norway

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 928 150

Participants (10)

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UNIVERSITAET ULM

Germany

EU Contribution

€ 660 270

UNIVERSITAT DES SAARLANDES

Germany

EU Contribution

€ 613 875

TECHNISCHE UNIVERSITAET WIEN

Austria

EU Contribution

€ 673 266,25

BIO BASE EUROPE PILOT PLANT VZW

Belgium

EU Contribution

€ 438 473,75

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA

Spain

EU Contribution

€ 179 390

NORGES MILJO-OG BIOVITENSKAPLIGE UNIVERSITET

Norway

EU Contribution

€ 146 500

BORREGAARD AS

Norway

GALACTIC SA

Belgium

MYBIOTECH GMBH

Germany

EU Contribution

€ 128 025

INFORS AG

Switzerland

EU Contribution

€ 229 875

Project information

Grant agreement ID: 790507

Status

Ongoing project

  • Start date

    1 May 2018

  • End date

    30 April 2022

Funded under:

H2020-EU.3.2.6.1.

  • Overall budget:

    € 5 360 381,25

  • EU contribution

    € 3 997 825

Coordinated by:

NORGES TEKNISK-NATURVITENSKAPELIGE UNIVERSITET NTNU

Norway