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Risultati finali

Movie - demonstration

Movie demonstration

External website of iFermenter

External website of iFermenter open to the public, but also has secured login intranet pages to share secure internal information

Initial Environmental impact assessment

Environmental impact assessment of the new strain, successfully demonstrating 20% reduction of CO2 in milliscales laboratory conditions

Developed (reduced) 3 models for the levels

Developed reduced 3 models for the levels genome metabolic and process Model predictions have satisfactory error margins 25 when compared to data D32 D34 D36

Successful demonstration of 20% reduction in CO2 footprint from the upscaled industrial process, by an LCA report

Successful demonstration of 20 reduction in CO2 footprint from the upscaled industrial process by an LCA report Environmental and demonstrating potential costs of upscaling the process O4b

Metabolic model, describing different physiological states of the cell factories

Metabolic model describing different physiological states of the cell factories

Genome network reduced dynamic mode

Genome network reduced dynamic mode

Process level reduced dynamic model

Process level reduced dynamic model


Recombinant production of the lantibiotic nisin using <i>Corynebacterium glutamicum</i> in a two-step process

Autori: Dominik Weixler; Max Berghoff; Kirill V. Ovchinnikov; Sebastian Reich; Oliver Goldbeck; Gerd M. Seibold; Christoph Wittmann; Nadav S. Bar; Bernhard J. Eikmanns; Dzung B. Diep; Christian U. Riedel
Pubblicato in: Microbial Cell Factories, Issue 1, 2022, ISSN 1475-2859
Editore: BioMed Central
DOI: 10.1186/s12934-022-01739-y

Sensor fusion based on Extended and Unscented Kalman Filter for bioprocess monitoring

Autori: Andrea Tuveri; Fernando Pérez-García; Pedro A. Lira-Parada; Lars Imsland; Nadav Bar
Pubblicato in: Journal of Process Control, Issue 2, 2021, ISSN 0959-1524
Editore: Butterworth Scientific Ltd.
DOI: 10.1016/j.jprocont.2021.09.005

Waste biorefinery towards a sustainable biotechnological production of pediocin: Synergy between process simulation and environmental assessment

Autori: Ana Arias, Daniel Barreiro, Gumersindo Feijoo, Maria Teresa Moreira
Pubblicato in: Environmental Technology & Innovation, Issue 26, 2022, ISSN 2352-1864
Editore: Elsevier BV
DOI: 10.1016/j.eti.2022.102306

Establishing recombinant production of pediocin PA-1 in Corynebacterium glutamicum

Autori: Oliver Goldbeck, Dominique N. Desef, Kirill V. Ovchinnikov, Fernando Perez-Garcia, Jens Christmann, Peter Sinner, Peter Crauwels, Dominik Weixler, Peng Cao, Judith Becker, Michael Kohlstedt, Julian Kager, Bernhard J. Eikmanns, Gerd M. Seibold, Christoph Herwig, Christoph Wittmann, Nadav S. Bar, Dzung B. Diep, Christian U. Riedel
Pubblicato in: Metabolic Engineering, 2021, ISSN 1096-7176
Editore: Academic Press
DOI: 10.1016/j.ymben.2021.09.002

Inventory review and environmental evaluation of first- and second-generation sugars through life cycle assessment.

Autori: Sara Bello; Iana Salim; Gumersindo Feijoo; Maria Teresa Moreira
Pubblicato in: Environmental Science and Pollution Research, Issue 3, 2021, ISSN 0944-1344
Editore: Springer Verlag
DOI: 10.1007/s11356-021-12405-y

Dynamic Co-Cultivation Process of Corynebacterium glutamicum Strains for the Fermentative Production of Riboflavin

Autori: Fernando Pérez-García, Arthur Burgardt, Dina R. Kallman, Volker F. Wendisch, Nadav Bar
Pubblicato in: Fermentation, Issue 7/1, 2021, Page(s) 11, ISSN 2311-5637
Editore: MDPI
DOI: 10.3390/fermentation7010011

In Silico Prediction and Analysis of Unusual Lantibiotic Resistance Operons in the Genus Corynebacterium

Autori: Oliver Goldbeck, Dominik Weixler, Bernhard J. Eikmanns, Christian U. Riedel
Pubblicato in: Microorganisms, Issue 9/3, 2021, Page(s) 646, ISSN 2076-2607
Editore: MDPI
DOI: 10.3390/microorganisms9030646

Advances in metabolic engineering of Corynebacterium glutamicum to produce high-value active ingredients for food, feed, human health, and well-being

Autori: Sabrina Wolf, Judith Becker, Yota Tsuge, Hideo Kawaguchi, Akihiko Kondo, Jan Marienhagen, Michael Bott, Volker F. Wendisch, Christoph Wittmann
Pubblicato in: Essays in Biochemistry, 2021, ISSN 0071-1365
Editore: Portland Press, Ltd.
DOI: 10.1042/ebc20200134

The use of maize stover and sugar beet pulp as feedstocks in industrial fermentation plants – An economic and environmental perspective

Autori: Iana Câmara-Salim; Pablo Conde; Gumersindo Feijoo; Maria Teresa Moreira
Pubblicato in: Cleaner Environmental Systems, Issue 3, 2021, ISSN 2666-7894
Editore: Elsevier
DOI: 10.1016/j.cesys.2020.100005

Technological feasibility and environmental assessment of polylactic acid-nisin-based active packaging.

Autori: Arias, A., Feijoo, G. & Moreira, M.T.
Pubblicato in: Sustainable Materials and Technologies, 2022, ISSN 2214-9937
Editore: Elsevier
DOI: 10.1016/j.susmat.2022.e00460

Linking process and metabolic modelling for the estimation of carbon flux distribution in Corynebacterium glutamicum growth in spent sulfite liquor

Autori: Pedro A.Lira-Parada, PeterSinner, MichaelKohlstedt, JulianKager, ChristophWittmann, ChristophHerwig, NadavBar
Pubblicato in: IFAC-PapersOnLine, 2022, ISSN 2405-8963
Editore: Elsevier
DOI: 10.1016/j.ifacol.2022.07.449

BECCS based on bioethanol from wood residues: Potential towards a carbon-negative transport and side-effects

Autori: Sara Bello, Ángel Galán-Martín, Gumersindo Feijoo, Maria Teresa Moreira, Gonzalo Guillén-Gosálbez
Pubblicato in: Applied Energy, Issue 279, 2020, Page(s) 115884, ISSN 0306-2619
Editore: Pergamon Press Ltd.
DOI: 10.1016/j.apenergy.2020.115884

Noninvasive online monitoring of Corynebacterium glutamicum fed-batch bioprocesses subject to spent sulfite liquor raw material uncertainty

Autori: Peter Sinner, Marlene Stiegler, Christoph Herwig, Julian Kager
Pubblicato in: Bioresource Technology, Issue 321, 2021, Page(s) 124395, ISSN 0960-8524
Editore: Elsevier BV
DOI: 10.1016/j.biortech.2020.124395

The Increasing Issue of Vancomycin-Resistant Enterococci and the Bacteriocin Solution

Autori: Ingvild S. Reinseth, Kirill V. Ovchinnikov, Hanne H. Tønnesen, Harald Carlsen, Dzung B. Diep
Pubblicato in: Probiotics and Antimicrobial Proteins, 2019, ISSN 1867-1306
Editore: Springer Pub. Co.,
DOI: 10.1007/s12602-019-09618-6

Model-based Analysis and Optimisation of a Continuous Corynebacterium glutamicum Bioprocess Utilizing Lignocellulosic Waste

Autori: Peter Sinner, Julian Kager, Sven Daume, Christoph Herwig
Pubblicato in: IFAC-PapersOnLine, 2019, ISSN 2405-8963
Editore: Elsevier

The Industrial Organism Corynebacterium glutamicum Requires Mycothiol as Antioxidant to Resist Against Oxidative Stress in Bioreactor Cultivations

Autori: Fabian Stefan Franz Hartmann, Lina Clermont, Quach Ngoc Tung, Haike Antelmann, Gerd Michael Seibold
Pubblicato in: Antioxidants, Issue 9/10, 2020, Page(s) 969, ISSN 2076-3921
Editore: MDPI
DOI: 10.3390/antiox9100969

Establishing the multi-criteria roadmap and metrics for the evaluation of active films for food packaging

Autori: Arias, A., Feijoo, G., & Moreira, M. T.
Pubblicato in: Current Research in Green and Sustainable Chemistry, Issue 4, 2021, ISSN 2666-0865
Editore: Elsevier
DOI: 10.1016/j.crgsc.2021.100160

Process and environmental simulation in the validation of the biotechnological production of nisin from waste

Autori: Arias, A., Feijoo, G., & Moreira, M. T.
Pubblicato in: Biochemical Engineering Journal, Issue 174, 2021, ISSN 1369-703X
Editore: Elsevier BV
DOI: 10.1016/j.bej.2021.108105

Time Scale Analysis and Optimization of a Continuous Microbial Bioprocess

Autori: Peter Sinner, Christoph Herwig, Julian Kager
Pubblicato in: 30th European Symposium on Computer Aided Process Engineering, Issue 48, 2020, Page(s) 1603-1608, ISBN 9780128233771
Editore: Elsevier
DOI: 10.1016/b978-0-12-823377-1.50268-8

Usage of Digital Twins Along a Typical Process Development Cycle

Autori: Peter Sinner, Sven Daume, Christoph Herwig, Julian Kager
Pubblicato in: Digital Twins - Tools and Concepts for Smart Biomanufacturing, Issue 176, 2021, Page(s) 71-96, ISBN 978-3-030-71659-2
Editore: Springer International Publishing
DOI: 10.1007/10_2020_149


Autori: Andrea Tuveri, Pedro LIra, Fernando Perez-Garcia, Nadav Bar
Pubblicato in: IFAC FOSBE 19, Issue 17th October 2019, 2019
Editore: Elsevier

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