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Long-retention liposomic drug-delivery for intra-articular osteoarthritis therapy

Long-retention liposomic drug-delivery for intra-articular osteoarthritis therapy

Objective

Osteoarthritis (OA) is the most widespread joint disease, affecting millions and imposing a huge individual and socio-economic burden. The creation of liposomes functionalised with novel (IP-protected) molecules that greatly extend (by almost an order of magnitude) their half-life in joints following IA injection, relative to existing approaches, and the alleviation of OA that may arise through exploiting this longer retention, is the basis of this proof of concept project. The main innovation step is functionalizing liposomes with our novel molecules to provide much longer retention drug-delivery vehicles, which therefore provide greater benefits in therapy relative to existing approaches, and so should be preferred by patients. Its practical implementation, to advance and investigate the potential for long-retention IA drug-delivery and other uses, will be carried out both through validation on animals (proof-of-concept), through suitable pre-commercialisation studies, networking and identifying potential partners, and developing a business plan. Hence, we propose to validate the concept of creating new products that will be available commercially for IA delivery, implementing the long-retention in the joints which greatly enhances their usefulness and which is the basis of the present innovation step.
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Host institution

WEIZMANN INSTITUTE OF SCIENCE LTD

Address

Herzl Street 234
7610001 Rehovot

Israel

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 150 000

Beneficiaries (1)

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WEIZMANN INSTITUTE OF SCIENCE LTD

Israel

EU Contribution

€ 150 000

Project information

Grant agreement ID: 812577

Status

Ongoing project

  • Start date

    1 July 2018

  • End date

    31 December 2019

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 150 000

  • EU contribution

    € 150 000

Hosted by:

WEIZMANN INSTITUTE OF SCIENCE LTD

Israel