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3D printed COLLagen type I-Hydroxyapatite prostheses for the middle EAR

Objective

Conductive hearing loss is a pathology that affects about 15% of the worldwide population and more than 40% of the elderly. So far, passive implants, made of titanium and hydroxyapatite, are the preferred solution to restore the middle ear function. Unfortunately, a significant percentage of extrusion still occurs (up to 40% in the long term) due to reduced biocompatibility. The applicant (i.e. experienced researcher, ER) studied ear micro-prosthetics during his PhD and aims at developing a new generation of 3D printed bulk micro-prostheses for the middle ear made of collagen type 1 and hydroxyapatite, namely, the native components of the ear bones, to improve the quality of life the European citizens, who are highly prone to conductive deafness due to their longevity. To achieve this ambitious goal, thus maximising the acoustic behaviour of the composite material from its basic unit, the ER needs to learn multiscale design (i.e. from the atomic- to the macro-scale), which will be addressed during the outgoing phase at MIT. Therefore, a dedicated study will be carried out on 3D printing techniques in order to fabricate a set of new prototypes, which will be challenging due to the small size versus high performance of the ossicular prostheses. The ER will investigate and characterize the newly designed prostheses from a topological and acousto-mechanical standpoint at University of Antwerp (2-month secondment) and through a dedicated bioreactor, designed and manufactured on purpose at Scuola Superiore Sant’Anna (Beneficiary) to be used for a biologic assessment at University of Pisa (4-month secondment). The multidisciplinary approach involving acoustics, materials science, engineering, biology and otology will enhance the development of innovative clinically oriented prototypes and will contribute to the ER’s scientific and personal growth in view of a future academic or industrial independent position, based on high specialized skills and international networking.

Field of science

  • /medical and health sciences/basic medicine/pathology
  • /natural sciences/chemical sciences/inorganic chemistry/inorganic compounds
  • /medical and health sciences/clinical medicine/otorhinolaryngology
  • /engineering and technology/environmental biotechnology/bioremediation/bioreactor
  • /natural sciences/physical sciences/acoustics
  • /medical and health sciences/medical biotechnology/medical bioproducts/implants

Call for proposal

H2020-MSCA-IF-2017
See other projects for this call

Funding Scheme

MSCA-IF-GF - Global Fellowships

Coordinator

SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA
Address
Piazza Martiri Della Liberta 33
56127 Pisa
Italy
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 244 269

Partners (1)

MASSACHUSETTS INSTITUTE OF TECHNOLOGY
United States
Address
Massachusetts Avenue 77
02139 Cambridge
Activity type
Higher or Secondary Education Establishments