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Molecular logic lab-on-a-vesicle for intracellular diagnostics

Objective

A dysfunction of cells lining the inner walls of blood vessels, i.e. the endothelium, is the primary cause of many lifestyle related diseases. According to the WHO, those diseases accounted for 60% of all deaths worldwide in 2005. Tailor-made diagnostic tools for early and reliable identification of endothelial dysfunction are urgently needed both in fundamental research and clinical routine, respectively.
The Marie Skłodowska-Curie action LOGIC LAB objects to develop and characterize innovative molecular logic gates that can be applied as advanced diagnostic tools for parallel analyte sensing in live mammalian cells. Thereby, providing a unique method to discover endothelial dysfunction and the onset of diseases much easier and earlier than so far.
LOGIC LAB creates a multi-faceted and multi-sectoral research environment for the next generation of scientists in order to establish a novel type of molecular logic sensors that reliably operate in biological media – a crucial requirement for their application i.e. as rapid and easy-to-handle tools for intracellular diagnostics.
With excellent cross-disciplinary scientific and complementary training provided in the network, we aim to educate highly-skilled young scientists in the fields of chemistry, physics and biology, who will significantly strengthen the international research community in the domain of molecular logic sensing. Thus, in the long term, LOGIC LAB aims to finally bridge the gap between lab bench and biological or medical practice. It is this gap, that so far prevents a wide-ranging use of existing molecular logic gates e.g. for the diagnosis of lifestyle-associated diseases.

Call for proposal

H2020-MSCA-ITN-2018
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

LEIBNIZ-INSTITUT FUER PHOTONISCHE TECHNOLOGIEN E.V.
Address
Albert Einstein Strasse 9
07745 Jena
Germany
Activity type
Research Organisations
EU contribution
€ 505 576,80

Participants (8)

DUBLIN CITY UNIVERSITY
Ireland
EU contribution
€ 549 368,64
Address
Glasnevin
9 Dublin
Activity type
Higher or Secondary Education Establishments
FRIEDRICH-SCHILLER-UNIVERSITAT JENA
Germany
EU contribution
€ 252 788,40
Address
Furstengraben 1
07743 Jena
Activity type
Higher or Secondary Education Establishments
POLITECHNIKA GDANSKA
Poland
EU contribution
€ 227 478,60
Address
Ul. Gabriela Narutowicza 11/12
80-233 Gdansk
Activity type
Higher or Secondary Education Establishments
UNIWERSYTET JAGIELLONSKI
Poland
EU contribution
€ 454 957,20
Address
Ul. Golebia 24
31007 Krakow
Activity type
Higher or Secondary Education Establishments
EXPERIMENTAL MEDICINE CENTRE OF THE SLOVAK ACADEMY OF SCIENCES
Slovakia
EU contribution
€ 233 246,88
Address
Dubravska Cesta 9
841 04 Bratislava
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
UNIVERSITEIT LEIDEN
Netherlands
EU contribution
€ 796 859,64
Address
Rapenburg 70
2311 EZ Leiden
Activity type
Higher or Secondary Education Establishments
MIMETAS BV
Netherlands
EU contribution
€ 265 619,88
Address
Jh Oortweg 19
2333CH Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SCICLUS GMBH & CO. KG
Germany
EU contribution
€ 252 788,40
Address
Moritz-von Rohr-str. 1A
07745 Jena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (6)

COSMOLOGIC GMBH & COKG
Germany
Address
Imbacher Weg 46
51379 Leverkussen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MATTEK IN VITRO LIFE SCIENCE LABORATORIES SRO
Slovakia
Address
Mlynske Nivy 73
821 05 Bratislava
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DYOMICS GMBH
Germany
Address
Otto-schott-st 15
07745 Jena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MICROFLUIDIC CHIPSHOP GMBH
Germany
Address
Stockholmer Strasse 20
07747 Jena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INTERSCIENCE BV
Netherlands
Address
Tinstraat 16
4823 AA Breda
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Alexander Schiller
Germany
Address
Am Steiger 9
07743 Jena
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)