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Enabling proteins with RNA recognition motifs for synthetic biology and bio-analytics.

Enabling proteins with RNA recognition motifs for synthetic biology and bio-analytics.

Objective

RNAct creates an integrated and multidisciplinary training and research programme for 10 broadly employable ESRs with versatile computational and experimental skills. The RNAct research aim is the design of novel RNA recognition motif (RRM) proteins for exploitation in synthetic biology and bio-analytics. This is achieved through a design cycle that starts with computational approaches at the sequence and structure levels of proteins and RNA, in order to select amino acid positions and mutations for large-scale phage display experiments with RNA screening. Viable RRMs will be further investigated at the atomic level with integrative structural biology approaches, and will be applied in synthetic biology, to post-transcriptionally regulate fatty acid processing via RRMs, and in bio-analytics, to detect RNA in-cell and design RNA biochips. The RNAct training will provide ESR-tailored research and education-based training in both topical content and transversal skills. All ESRs will experience both academic and industrial environments, and will be exposed to both computation and experiment at the peer level via an ESR 'buddy' system. The ESRs will be actively involved in, and responsible for, information dissemination and communication for the RNAct project, and will have to opportunity to participate in innovation activities. This will enable the ESRs to constructively contribute to the European bio-economy in both academic and industrial settings.
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Coordinator

VRIJE UNIVERSITEIT BRUSSEL

Address

Pleinlaan 2
1050 Brussel

Belgium

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 512 640

Participants (6)

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CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 549 604,08

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

Germany

EU Contribution

€ 505 576,80

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 250 904,88

GIOTTO BIOTECH SRL

Italy

EU Contribution

€ 261 499,68

DYNAMIC BIOSENSORS GMBH

Germany

EU Contribution

€ 252 788,40

RIDGEVIEW INSTRUMENTS AB

Sweden

EU Contribution

€ 281 982,96

Partners (7)

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TECHNISCHE UNIVERSITAET MUENCHEN

UNIVERSITAT POLITECNICA DE VALENCIA

UNIVERSITA DEGLI STUDI DI FIRENZE

UPPSALA UNIVERSITET

UNIVERSITE DE LORRAINE

UNIVERSITE DE LIEGE

"UAB ""Spronk NMR Consultancy"""

Project information

Grant agreement ID: 813239

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2022

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 2 614 996,80

  • EU contribution

    € 2 614 996,80

Coordinated by:

VRIJE UNIVERSITEIT BRUSSEL

Belgium