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Chromatin architecture and Design

Objective

ChromDesign is an innovative and interdisciplinary network of 10 European academic and private institutions that will characterize how 3D chromatin organization affects gene regulation during cellular differentiation and in several human disorders. We will train 13 Early Stage Researchers (ESR), equipping them with the skills, knowledge, expertise, and enthusiasm necessary to develop successful future careers in the biomedical field (in academia or the private sector). Together with European experts in chromatin biology, 3D genomics, and research design, these ESRs will work towards the goal of identifying novel alterations in chromatin topology responsible for cellular malfunctions to: i) develop new diagnostic tools, ii) effectively communicate research results through specific toolkits; and iii) identify novel therapeutic targets with the potential to be exploited as treatments.
Alteration of gene regulation occurs naturally during aging and underlies several human diseases. Its better characterization requires a deeper understanding of the spatial organization of the genome. We will investigate how the genome organizes in 3D over time, and how the 3D organization is related to gene regulation in health and disease. We will use and develop technologies in imaging, cell biology, genomics, and computational modelling and will focus on translating our results into clinical applications. ESRs will thereby receive training with state-of-the-art technologies in distinct research areas and in modules with theoretical and hands-on sessions on transferable skills: entrepreneurship, management, communication, and outreach.
ChromDesign comprises 6 work packages: WP1–4 address the 4 main areas of chromatin biology and 3D genomics; WP5 applies the knowledge obtained from WPs1–4 into translational research; WP6 develops (with a dedicated ESR) a set of design toolkits for communicating results to scientists, the public, and schools; and WP7 ensures quality training for ESRs.

Coordinator

FUNDACIO CENTRE DE REGULACIO GENOMICA
Net EU contribution
€ 752 714,64
Address
Carrer Doctor Aiguader 88
08003 Barcelona
Spain
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (10)

KOBENHAVNS UNIVERSITET
Denmark
Net EU contribution
€ 297 522,00
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FUNDACIO PRIVADA ELISAVA ESCOLA UNIVERSITARIA
Spain
Net EU contribution
€ 250 904,88
Address
La Rambla 30-32
08002 Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
Switzerland
Net EU contribution
€ 281 276,64
Address
Maulbeerstrasse 66
4058 Basel
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
Net EU contribution
€ 252 788,40
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
Non-EU contribution
€ 0,00
INSTITUT CURIE
France
Net EU contribution
€ 274 802,04
Address
Rue D'ulm 26
75231 Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
Net EU contribution
€ 252 788,40
Address
Hofgartenstrasse 8
80539 Munchen
Activity type
Research Organisations
Non-EU contribution
€ 0,00
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
Net EU contribution
€ 274 802,04
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
ISTITUTO EUROPEO DI ONCOLOGIA SRL
Italy
Net EU contribution
€ 261 499,68
Address
Via Filodrammatici 10
20121 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
DIAGENODE
Belgium
Net EU contribution
€ 256 320,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Rue Du Bois Saint Jean 3 Liege Park Science
4102 Seraing
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germany
Net EU contribution
€ 252 788,40
Address
Meyerhofstrasse 1
69117 Heidelberg
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis

Partners (6)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

UNIVERSITE DE MONTPELLIER
France
Net EU contribution
€ 0,00
Address
163 Rue Auguste Broussonnet
34090 Montpellier
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Occitanie Languedoc-Roussillon Hérault
 
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

BYFACILITY SL
Spain
Net EU contribution
€ 0,00
Address
C/pujades 77 3 6
08005 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

surfrender
Netherlands
Net EU contribution
€ 0,00
Address
Tongelresestraat 449
5641AW Eindhoven
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

EUROPEAN MOLECULAR BIOLOGY ORGANIZATION
Switzerland
Net EU contribution
€ 0,00
Address
Rue De La Mairie 35
1207 Geneve
Activity type
Other
Non-EU contribution
€ 0,00
Region
Schweiz/Suisse/Svizzera Région lémanique Genève
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

FUNDACIO D'ESTUDIS I RECERCA ONCOLOGICA (FERO)
Spain
Net EU contribution
€ 0,00
Address
Sardenya 229-237, S.atico 3A
08013 Barcelona
Activity type
Other
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Net EU contribution
€ 0,00
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
East of England East Anglia Cambridgeshire CC