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A multidisciplinary approach towards sustainable improvement in rare diseases care uniting Europe's top class vascular research to find new treatment strategies for vascular anomalies

Objective

Vascular anomalies (VAs) is a group of rare diseases defined by blood- or lymph vessel dysfunction causing chronic pain, disabilities, and even sudden death, and for which effective treatments are lacking. The European V.A. Cure network aims to address this unmet medical need by uncovering core mechanisms of disease initiation and maintenance and by leveraging this information for establishing novel therapeutic strategies for VAs.
V.A. Cure has assembled 7 world-leading academic laboratories and 5 companies, which will apply an intersectoral four-step approach: (1) identification of novel genes involved in VAs in patients, (2) dissection of molecular mechanisms behind the diseases by in vitro modelling, (3) in-depth analysis of tissular mechanisms in pathophysiological conditions through in vivo models, and (4) pre-clinical testing of identified treatment strategies. The knowledge gained will not only be relevant for VAs but also for understanding aberrant vascular function in other vascular-related diseases.
The composition of V.A. Cure and close interaction between the 14 ESRs, through secondments in academia and industry, guarantee a unique intersectoral training program at the highest level, ensuring a comprehensive perception of research and drug/technology development in pharma industry/biotech and academia. ESRs will be trained in a plethora of cutting-edge technologies including next-generation sequencing (up to single-cell RNA-Seq), CRISPR-Cas genome editing, generation of animal models with inducible deletion and mosaic analyses, generation of iPSCs, microfluidics, in vivo phage display to identify endothelial targets, and light sheet-, confocal-, and multiphoton live-imaging. In combination with advanced training in management and communication including writing, presentation, e-media and outreach, the graduates of the V.A. Cure network will be future leaders in vascular research, and also highly competitive candidates for positions outside academia.

Call for proposal

H2020-MSCA-ITN-2018
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

DE DUVE INSTITUTE AISBL
Address
Avenue Hippocrate 75/50
1200 Bruxelles
Belgium
Activity type
Research Organisations
EU contribution
€ 512 640

Participants (8)

UPPSALA UNIVERSITET
Sweden
EU contribution
€ 563 965,92
Address
Von Kraemers Alle 4
751 05 Uppsala
Activity type
Higher or Secondary Education Establishments
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 252 788,40
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 281 982,96
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET POTSDAM
Germany
EU contribution
€ 505 576,80
Address
Am Neuen Palais 10
14469 Potsdam
Activity type
Higher or Secondary Education Establishments
OULUN YLIOPISTO
Finland
EU contribution
€ 280 805,76
Address
Pentti Kaiteran Katu 1
90014 Oulu
Activity type
Higher or Secondary Education Establishments
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 549 604,08
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
SINGH PRATEEK
Finland
EU contribution
€ 280 805,76
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ASTRAZENECA AB
Sweden
EU contribution
€ 563 965,92
Address
Vastra Maelarhamnen
151 85 Sodertaelje
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (8)

TAMPEREEN KORKEAKOULUSAATIO SR
Finland
Address
Kalevantie 4
33100 Tampere
Activity type
Higher or Secondary Education Establishments
Sysmex Inostics GmbH
Germany
Address
Falkenried 88
20251 Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BAYER AKTIENGESELLSCHAFT
Germany
Address
Kaiser-wilhelm-allee 1
51373 Leverkusen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Perimed AB
Sweden
Address
Datavägen 9A
17526 Järfälla
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
LLS ROWIAK LASERLABSOLUTIONS GMBH
Germany
Address
Garbsener Landstrasse 10
30419 Hannover
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BELGIAN VASCULAR ANOMALY PATIENT ASSOCIATION
Belgium
Address
Avenue Baron Albert D'huart 192
1950 Kraainem
Activity type
Other
NAVINCI DIAGNOSTICS AB
Sweden
Address
Uppsala University Bmc D11 Plan 1 Husargatan 3
752 37 Uppsala
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CLINIQUES UNIVERSITAIRES SAINT-LUC
Belgium
Address
Avenue Hippocrate 10
1200 Bruxelles
Activity type
Research Organisations