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A multidisciplinary approach towards sustainable improvement in rare diseases care uniting Europe's top class vascular research to find new treatment strategies for vascular anomalies

Objective

Vascular anomalies (VAs) is a group of rare diseases defined by blood- or lymph vessel dysfunction causing chronic pain, disabilities, and even sudden death, and for which effective treatments are lacking. The European V.A. Cure network aims to address this unmet medical need by uncovering core mechanisms of disease initiation and maintenance and by leveraging this information for establishing novel therapeutic strategies for VAs.
V.A. Cure has assembled 7 world-leading academic laboratories and 5 companies, which will apply an intersectoral four-step approach: (1) identification of novel genes involved in VAs in patients, (2) dissection of molecular mechanisms behind the diseases by in vitro modelling, (3) in-depth analysis of tissular mechanisms in pathophysiological conditions through in vivo models, and (4) pre-clinical testing of identified treatment strategies. The knowledge gained will not only be relevant for VAs but also for understanding aberrant vascular function in other vascular-related diseases.
The composition of V.A. Cure and close interaction between the 14 ESRs, through secondments in academia and industry, guarantee a unique intersectoral training program at the highest level, ensuring a comprehensive perception of research and drug/technology development in pharma industry/biotech and academia. ESRs will be trained in a plethora of cutting-edge technologies including next-generation sequencing (up to single-cell RNA-Seq), CRISPR-Cas genome editing, generation of animal models with inducible deletion and mosaic analyses, generation of iPSCs, microfluidics, in vivo phage display to identify endothelial targets, and light sheet-, confocal-, and multiphoton live-imaging. In combination with advanced training in management and communication including writing, presentation, e-media and outreach, the graduates of the V.A. Cure network will be future leaders in vascular research, and also highly competitive candidates for positions outside academia.

Coordinator

DE DUVE INSTITUTE AISBL
Net EU contribution
€ 512 640,00
Address
Avenue Hippocrate 75/50
1200 Bruxelles
Belgium

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (8)

UPPSALA UNIVERSITET
Sweden
Net EU contribution
€ 563 965,92
Address
Von Kraemers Alle 4
751 05 Uppsala

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Region
Östra Sverige Östra Mellansverige Uppsala län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
Net EU contribution
€ 252 788,40
Address
Hofgartenstrasse 8
80539 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Non-EU contribution
€ 0,00
KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 281 982,96
Address
Nobels Vag 5
17177 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAET POTSDAM
Germany
Net EU contribution
€ 505 576,80
Address
Am Neuen Palais 10
14469 Potsdam

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Region
Brandenburg Brandenburg Potsdam
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
OULUN YLIOPISTO
Finland
Net EU contribution
€ 280 805,76
Address
Pentti Kaiteran Katu 1
90014 Oulu

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Region
Manner-Suomi Pohjois- ja Itä-Suomi Pohjois-Pohjanmaa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 549 604,08
Address
Rue De Tolbiac 101
75654 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
SINGH PRATEEK
Finland
Net EU contribution
€ 280 805,76
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
ASTRAZENECA AB
Sweden
Net EU contribution
€ 563 965,92
Address
Vastra Maelarhamnen
151 85 Sodertaelje

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00

Partners (8)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

TAMPEREEN KORKEAKOULUSAATIO SR
Finland
Net EU contribution
€ 0,00
Address
Kalevantie 4
33100 Tampere

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Region
Manner-Suomi Länsi-Suomi Pirkanmaa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Sysmex Inostics GmbH
Germany
Net EU contribution
€ 0,00
Address
Falkenried 88
20251 Hamburg

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Region
Hamburg Hamburg Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

BAYER AKTIENGESELLSCHAFT
Germany
Net EU contribution
€ 0,00
Address
Kaiser-wilhelm-allee 1
51373 Leverkusen

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Region
Nordrhein-Westfalen Köln Leverkusen, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Perimed AB
Sweden
Net EU contribution
€ 0,00
Address
Datavägen 9a
17526 Järfälla

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Östra Sverige Stockholm Stockholms län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

LLS ROWIAK LASERLABSOLUTIONS GMBH
Germany
Net EU contribution
€ 0,00
Address
Garbsener Landstrasse 10
30419 Hannover

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Niedersachsen Hannover Region Hannover
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

BELGIAN VASCULAR ANOMALY PATIENT ASSOCIATION
Belgium
Net EU contribution
€ 0,00
Address
Avenue Baron Albert D'huart 192
1950 Kraainem

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Region
Vlaams Gewest Prov. Vlaams-Brabant Arr. Halle-Vilvoorde
Activity type
Other
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

NAVINCI DIAGNOSTICS AB
Sweden
Net EU contribution
€ 0,00
Address
Uppsala University Bmc D11 Plan 1 Husargatan 3
752 37 Uppsala

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Östra Sverige Östra Mellansverige Uppsala län
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

CLINIQUE UNIVERSITAIRE SAINT-LUC ASBL
Belgium
Net EU contribution
€ 0,00
Address
Avenue Hippocrate 10
1200 Bruxelles

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Region
Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
Activity type
Other
Non-EU contribution
€ 0,00