Cel Biohybrid MicroRobots (BMRs) are conceptual microscopic robotic devices that combine synthetic and biological components and can be remote controlled to a specific destination, attach to a target and perform a bespoke biochemical operation at nanoscale precision. Within the 5-year Microrobots project, I intend to develop innovative BMRs by combining magnetic swimmers (MSs) with prokaryotic S-layers (SLs). MSs are microscopic devices that consist of two flexibly linked metallic beads with different magnetic properties and can be remote controlled through liquid media, simply by applying oscillating magnetic fields. SLs are highly stable 2-dimensional protein arrays that form resilient cell wall components in archaea and bacteria and can be genetically modified and reassembled on inorganic surfaces. I will introduce affinity tags into selected archaeal and bacterial SLs and reassemble them on the surfaces of MSs. This will coat MSs with unique affinity matrices, on which bioactive molecules can be conjugated at regular arrays, high density and defined distance. Through this strategy, I will generate BMRs that can be equipped with any bioactive functionality provided by nature, such as adhesive filaments, enzymes, antibodies, reporters, drug cargo or any other thinkable functional molecule. The BMRs that I will develop will elegantly miniaturise robotics and enable us to deliver bioactivity at nanometre precision. This will provide a revolutionary platform technology that will be applicable in a plethora of fields, such as medicine, nanotechnology, environmental engineering or scientific exploration and generate a real step change in the ways in which we build new materials, engineer our environment, fight disease and explore the universe in the 21st century. Dziedzina nauki natural sciencesbiological sciencesmicrobiologybacteriologyengineering and technologyenvironmental engineeringengineering and technologynanotechnologyengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringroboticsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Słowa kluczowe CryoEM magnetic swimmers S-layers adhesive filaments affinity tags Program(-y) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Temat(-y) ERC-2018-STG - ERC Starting Grant Zaproszenie do składania wniosków ERC-2018-STG Zobacz inne projekty w ramach tego zaproszenia System finansowania ERC-STG - Starting Grant Instytucja przyjmująca THE UNIVERSITY OF EXETER Wkład UE netto € 1 766 481,00 Adres THE QUEEN'S DRIVE NORTHCOTE HOUSE EX4 4QJ Exeter Zjednoczone Królestwo Zobacz na mapie Region South West (England) Devon Devon CC Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 1 766 481,00 Beneficjenci (1) Sortuj alfabetycznie Sortuj według wkładu UE netto Rozwiń wszystko Zwiń wszystko THE UNIVERSITY OF EXETER Zjednoczone Królestwo Wkład UE netto € 1 766 481,00 Adres THE QUEEN'S DRIVE NORTHCOTE HOUSE EX4 4QJ Exeter Zobacz na mapie Region South West (England) Devon Devon CC Rodzaj działalności Higher or Secondary Education Establishments Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Koszt całkowity € 1 766 481,00