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Research and Training in Early Life Nutrition to Prevent Disease

Research and Training in Early Life Nutrition to Prevent Disease

Objective

The interplay between nutrition, gut microbiota, and its large numberof metabolic and immune mediators plays an essential role in the development of gut immune homeostasis in early life. This interaction needs to be better understood because a disturbed immune function in the neonatal period is harmful for neonatal survival and enhances the risk of chronic inflammatory disease later in life. In particular, preterm infants have an immature gut and an associated intestinal state of dysbiosis, which limits the efficacy of nutritional interventions to 1) support early life nutrition, 2) prevent sepsis and conditions such as necrotizing enterocolitis and intestinal failure, and 3) reduce the risk of chronic inflammatory diseases mediated by the gut. A major barrier to elucidating the critical nutritional-host-microbiome interactions and reducing neonatal mortality is the lack of expertise in this rapidly emerging area of metabolomics. We therefore proposes a multidisciplinary approach making use of a large-scale pre-existing clinical cohort of neonates, and state of the art analytical and bio-informatics tools. GROWTH is an Innovative Training Network focused on European Industrial Doctorates that aims to train young business-oriented researchers in developing pathological insights, biomarker diagnostics and personalized nutritional interventions for intestinal failure in neonates and preterm infants. As a multidisciplinary consortium that will involve the participation of 7 non-academic and 5 academic partners in the life sciences field and will attempt shortening the path from basic research to clinical applications.

Coordinator

GUTRESEARCH BV

Address

Klokkenbergweg 8
1101 As Amsterdam

Netherlands

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

EU Contribution

€ 265 619,88

Participants (6)

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UNIVERSITAETSKLINIKUM BONN

Germany

EU Contribution

€ 505 576,80

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

EU Contribution

€ 303 172,56

RECKITT BENCKISER PLC

United Kingdom

EU Contribution

€ 303 172,56

Academisch Medisch Centrum bij de Universiteit van Amsterdam

Netherlands

EU Contribution

€ 265 619,88

CHERRY BIOTECH

France

EU Contribution

€ 274 802,04

STICHTING VUMC

Netherlands

EU Contribution

€ 265 619,88

Project information

Grant agreement ID: 814168

Status

Ongoing project

  • Start date

    1 June 2019

  • End date

    31 May 2023

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 2 183 583,60

  • EU contribution

    € 2 183 583,60

Coordinated by:

GUTRESEARCH BV

Netherlands