Theoretical and computational investigation of tuberculosis antimicrobial resistance development based on extensive experimental library of mycobacterium strains

Objective

Multidrug resistance of Mycobacterium tuberculosis is declared a serious global threat by the World Health Organization.
Our project aims at developing a comprehensive model of molecular mechanisms responsible for antimicrobial drug resistance of tuberculosis. Isoniazid is the main drug used for TB treatment, because it interacts with the bacterial catalase
that leads to the bacterial death. The library of isoniazid resistant strains (over 100 different strains) will be used as
experimental basis for building theoretical and computational models of the molecular processes leading to drug resistance
of mutated bacteria. The model will be used for suggesting effective treatment targeting these mechanisms and overcoming
the resistance.
AMR-TB RISE will be used to utilise the expertise of highly specialised research groups of biologists, clinicians, biochemists,
physicists, computer engineers, and mathematicians allowing the researches from these groups to work in multiple
laboratories of the Consortium all over the world. Particular attention will be given to training the next generation of young
researcher and forming tightly interconnected, long term collaboration devoted to solving the pressing global problem of antimicrobial resistance not only in TB, but in a wide spectrum of diseases.

Field of science

• /natural sciences/biological sciences/microbiology/bacteriology
• /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/antibiotic resistance
• /medical and health sciences/clinical medicine/pneumology/tuberculosis
• /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/multidrug resistance

Programme(s)

• H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge

Topic(s)

• MSCA-RISE-2018 - Research and Innovation Staff Exchange

Call for proposal

H2020-MSCA-RISE-2018
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

ASTON UNIVERSITY

Address

Aston Triangle
B4 7ET Birmingham
United Kingdom

Activity type

Higher or Secondary Education Establishments

EU contribution

€ 138 000

Participants (5)

INSTITUT BIOHIMII IM.O.V. PALLADINA NACIONALNOY AKADEMII NAUK UKRAINI

Ukraine

EU contribution

€ 423 200

Address

Leontovicha Street 9
01601 Kyiv

Activity type

Research Organisations

TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV

Ukraine

EU contribution

€ 87 400

Address

Volodymyrska St 60
01033 Kyiv

Activity type

Higher or Secondary Education Establishments

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU contribution

€ 9 200

Address

Calle Serrano 117
28006 Madrid

Activity type

Research Organisations

UNIVERSITY OF SURREY

United Kingdom

EU contribution

€ 27 600

Address

Stag Hill
GU2 7XH Guildford

Activity type

Higher or Secondary Education Establishments

UNIVERSITA DEGLI STUDI DI MESSINA

Italy

EU contribution

€ 46 000

Address

Piazza Pugliatti 1
98122 Messina

Activity type

Higher or Secondary Education Establishments

Partners (5)

FEDERAL STATE INSTITUTION SAINT PETERSBURG RESEARCH INSTITUTE OF PHTHISIOPULMONOLOGY OF THE FEDERAL AGENCY FOR HIGH TECHNOLOGY MEDICAL AID

Russia

Address

Ligovsky Prospekt 2-4
193063 Saint Petersburg

Activity type

Research Organisations

SAINT PETERSBURG STATE UNIVERSITY

Russia

Address

Universitetskaya Nab 7/9
199034 Saint Petersburg

Activity type

Higher or Secondary Education Establishments

KURSK STATE UNIVERSITY

Russia

Address

Radishcheva St 33
305000 Kursk

Activity type

Higher or Secondary Education Establishments

RIKEN THE INSTITUTE OF PHYSICAL ANDCHEMICAL RESEARCH

Japan

Address

Hirosawa 2-1
351 0198 Wako Shi Saitama

Activity type

Research Organisations

ESCUELA POLITECNICA NACIONAL

Ecuador

Address

Ladron De Guevara
17012759 Quito

Activity type

Higher or Secondary Education Establishments