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Theoretical and computational investigation of tuberculosis antimicrobial resistance development based on extensive experimental library of mycobacterium strains

Objective

Multidrug resistance of Mycobacterium tuberculosis is declared a serious global threat by the World Health Organization.
Our project aims at developing a comprehensive model of molecular mechanisms responsible for antimicrobial drug resistance of tuberculosis. Isoniazid is the main drug used for TB treatment, because it interacts with the bacterial catalase
that leads to the bacterial death. The library of isoniazid resistant strains (over 100 different strains) will be used as
experimental basis for building theoretical and computational models of the molecular processes leading to drug resistance
of mutated bacteria. The model will be used for suggesting effective treatment targeting these mechanisms and overcoming
the resistance.
AMR-TB RISE will be used to utilise the expertise of highly specialised research groups of biologists, clinicians, biochemists,
physicists, computer engineers, and mathematicians allowing the researches from these groups to work in multiple
laboratories of the Consortium all over the world. Particular attention will be given to training the next generation of young
researcher and forming tightly interconnected, long term collaboration devoted to solving the pressing global problem of antimicrobial resistance not only in TB, but in a wide spectrum of diseases.

Field of science

  • /natural sciences/biological sciences/microbiology/bacteriology
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/antibiotic resistance
  • /medical and health sciences/clinical medicine/pneumology/tuberculosis
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance/multidrug resistance

Call for proposal

H2020-MSCA-RISE-2018
See other projects for this call

Funding Scheme

MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE)

Coordinator

ASTON UNIVERSITY
Address
Aston Triangle
B4 7ET Birmingham
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 138 000

Participants (5)

INSTITUT BIOHIMII IM.O.V. PALLADINA NACIONALNOY AKADEMII NAUK UKRAINI
Ukraine
EU contribution
€ 423 200
Address
Leontovicha Street 9
01601 Kyiv
Activity type
Research Organisations
TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV
Ukraine
EU contribution
€ 87 400
Address
Volodymyrska St 60
01033 Kyiv
Activity type
Higher or Secondary Education Establishments
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 9 200
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
UNIVERSITY OF SURREY
United Kingdom
EU contribution
€ 27 600
Address
Stag Hill
GU2 7XH Guildford
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI MESSINA
Italy
EU contribution
€ 46 000
Address
Piazza Pugliatti 1
98122 Messina
Activity type
Higher or Secondary Education Establishments

Partners (5)

FEDERAL STATE INSTITUTION SAINT PETERSBURG RESEARCH INSTITUTE OF PHTHISIOPULMONOLOGY OF THE FEDERAL AGENCY FOR HIGH TECHNOLOGY MEDICAL AID
Russia
Address
Ligovsky Prospekt 2-4
193063 Saint Petersburg
Activity type
Research Organisations
SAINT PETERSBURG STATE UNIVERSITY
Russia
Address
Universitetskaya Nab 7/9
199034 Saint Petersburg
Activity type
Higher or Secondary Education Establishments
KURSK STATE UNIVERSITY
Russia
Address
Radishcheva St 33
305000 Kursk
Activity type
Higher or Secondary Education Establishments
RIKEN THE INSTITUTE OF PHYSICAL ANDCHEMICAL RESEARCH
Japan
Address
Hirosawa 2-1
351 0198 Wako Shi Saitama
Activity type
Research Organisations
ESCUELA POLITECNICA NACIONAL
Ecuador
Address
Ladron De Guevara
17012759 Quito
Activity type
Higher or Secondary Education Establishments