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Theoretical and computational investigation of tuberculosis antimicrobial resistance development based on extensive experimental library of mycobacterium strains

Project description

Tuberculosis antimicrobial resistance investigation using extensive library of mycobacterium strains

Antimicrobial drug resistance (AMR) in Mycobacterium tuberculosis is a global threat as declared by the World Health Organization. Presently, isoniazid represents the gold standard for tuberculosis (TB) treatment, interacting with the catalase enzyme and leading to bacterial death. Funded by the Marie Skłodowska-Curie Actions programme, the AMR-TB project aims to develop comprehensive models of the molecular mechanisms responsible for the multidrug resistance observed in TB. The international project team will utilise a library of more than 100 isoniazid-resistant strains to build theoretical computational models of the processes that lead to the development of AMR in mutated Mycobacteria. The goal is to apply the models to identify potential treatments targeting these mechanisms and overcome the resistance.

Objective

Multidrug resistance of Mycobacterium tuberculosis is declared a serious global threat by the World Health Organization.
Our project aims at developing a comprehensive model of molecular mechanisms responsible for antimicrobial drug resistance of tuberculosis. Isoniazid is the main drug used for TB treatment, because it interacts with the bacterial catalase
that leads to the bacterial death. The library of isoniazid resistant strains (over 100 different strains) will be used as
experimental basis for building theoretical and computational models of the molecular processes leading to drug resistance
of mutated bacteria. The model will be used for suggesting effective treatment targeting these mechanisms and overcoming
the resistance.
AMR-TB RISE will be used to utilise the expertise of highly specialised research groups of biologists, clinicians, biochemists,
physicists, computer engineers, and mathematicians allowing the researches from these groups to work in multiple
laboratories of the Consortium all over the world. Particular attention will be given to training the next generation of young
researcher and forming tightly interconnected, long term collaboration devoted to solving the pressing global problem of antimicrobial resistance not only in TB, but in a wide spectrum of diseases.

Coordinator

ASTON UNIVERSITY
Net EU contribution
€ 202 400,00
Address
ASTON TRIANGLE
B4 7ET Birmingham
United Kingdom

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Region
West Midlands (England) West Midlands Birmingham
Activity type
Higher or Secondary Education Establishments
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Total cost
€ 202 400,00

Participants (9)

Partners (5)