Project description DEENESFRITPL Tuberculosis antimicrobial resistance investigation using extensive library of mycobacterium strains Antimicrobial drug resistance (AMR) in Mycobacterium tuberculosis is a global threat as declared by the World Health Organization. Presently, isoniazid represents the gold standard for tuberculosis (TB) treatment, interacting with the catalase enzyme and leading to bacterial death. Funded by the Marie Skłodowska-Curie Actions programme, the AMR-TB project aims to develop comprehensive models of the molecular mechanisms responsible for the multidrug resistance observed in TB. The international project team will utilise a library of more than 100 isoniazid-resistant strains to build theoretical computational models of the processes that lead to the development of AMR in mutated Mycobacteria. The goal is to apply the models to identify potential treatments targeting these mechanisms and overcome the resistance. Show the project objective Hide the project objective Objective Multidrug resistance of Mycobacterium tuberculosis is declared a serious global threat by the World Health Organization.Our project aims at developing a comprehensive model of molecular mechanisms responsible for antimicrobial drug resistance of tuberculosis. Isoniazid is the main drug used for TB treatment, because it interacts with the bacterial catalasethat leads to the bacterial death. The library of isoniazid resistant strains (over 100 different strains) will be used asexperimental basis for building theoretical and computational models of the molecular processes leading to drug resistanceof mutated bacteria. The model will be used for suggesting effective treatment targeting these mechanisms and overcomingthe resistance.AMR-TB RISE will be used to utilise the expertise of highly specialised research groups of biologists, clinicians, biochemists,physicists, computer engineers, and mathematicians allowing the researches from these groups to work in multiplelaboratories of the Consortium all over the world. Particular attention will be given to training the next generation of youngresearcher and forming tightly interconnected, long term collaboration devoted to solving the pressing global problem of antimicrobial resistance not only in TB, but in a wide spectrum of diseases. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologymedical and health sciencesclinical medicinepneumologytuberculosismedical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistancemedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance Keywords antimicrobial resistance multidrug resistance isoniazide catalase molecular dynamics fitness landscape metabolic pathway Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge Topic(s) MSCA-RISE-2018 - Research and Innovation Staff Exchange Call for proposal H2020-MSCA-RISE-2018 See other projects for this call Funding Scheme MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Coordinator ASTON UNIVERSITY Net EU contribution € 202 400,00 Address ASTON TRIANGLE B4 7ET Birmingham United Kingdom See on map Region West Midlands (England) West Midlands Birmingham Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 202 400,00 Participants (9) Sort alphabetically Sort by Net EU contribution Expand all Collapse all INSTITUT BIOHIMII IM.O.V. PALLADINA NACIONALNOY AKADEMII NAUK UKRAINI Ukraine Net EU contribution € 248 400,00 Address LEONTOVICHA STREET 9 01601 Kyiv See on map Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 248 400,00 TARAS SHEVCHENKO NATIONAL UNIVERSITY OF KYIV Ukraine Net EU contribution € 96 600,00 Address VOLODYMYRSKA ST 60 01033 Kyiv See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 96 600,00 AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain Net EU contribution € 9 200,00 Address CALLE SERRANO 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 9 200,00 UNIVERSITY OF SURREY United Kingdom Net EU contribution € 13 800,00 Address Stag Hill GU2 7XH Guildford See on map Region South East (England) Surrey, East and West Sussex West Surrey Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 13 800,00 UNIVERSITA DEGLI STUDI DI MESSINA Italy Net EU contribution € 46 000,00 Address PIAZZA PUGLIATTI 1 98122 Messina See on map Region Isole Sicilia Messina Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 46 000,00 UNIVERSIDAD REY JUAN CARLOS Spain Net EU contribution € 41 400,00 Address CALLE TULIPAN 28933 Mostoles See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 41 400,00 GPU PRIME LTD United Kingdom Net EU contribution € 27 600,00 Address 16 ST THOMAS CLOSE CB23 7DN Cambridge See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region East of England East Anglia Cambridgeshire CC Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 27 600,00 FREIE UNIVERSITAET BERLIN Germany Net EU contribution € 9 200,00 Address KAISERSWERTHER STRASSE 16-18 14195 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 9 200,00 V. N. Karazin Kharkiv National University Ukraine Net EU contribution € 36 800,00 Address Svobody sq. 4 61077 Kharkiv See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 36 800,00 Partners (5) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. FEDERAL STATE INSTITUTION SAINT PETERSBURG RESEARCH INSTITUTE OF PHTHISIOPULMONOLOGY OF THE FEDERAL AGENCY FOR HIGH TECHNOLOGY MEDICAL AID Participation ended Russia Net EU contribution € 0,00 Address LIGOVSKY PROSPEKT 2-4 193063 SAINT PETERSBURG See on map Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. SAINT PETERSBURG STATE UNIVERSITY Participation ended Russia Net EU contribution € 0,00 Address UNIVERSITETSKAYA NAB 7/9 199034 SAINT PETERSBURG See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. KURSK STATE UNIVERSITY Participation ended Russia Net EU contribution € 0,00 Address RADISHCHEVA ST 33 305000 KURSK See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. RIKEN THE INSTITUTE OF PHYSICAL ANDCHEMICAL RESEARCH Japan Net EU contribution € 0,00 Address HIROSAWA 2-1 351 0198 WAKO SHI SAITAMA See on map Activity type Research Organisations Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. ESCUELA POLITECNICA NACIONAL Ecuador Net EU contribution € 0,00 Address LADRON DE GUEVARA 17012759 Quito See on map Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 18 400,00