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Membrane protein integrated technologies development for drug design

Membrane protein integrated technologies development for drug design

Objective

The aim of the ProMeTeus Consortium is to provide high-quality multidisciplinary knowledge through training and research on the development of protein studies as molecular tools for drug development and drug delivery. The focus of the action is the creation of a synergistic pipeline to yield target membrane protein structures and characterization and bioactive molecules design, harnessing the complementary skills from Academic and SME participants. We propose to join key expertise in protein structural biology and biochemistry with state-of-the art facilities for membrane protein high-throughput target selection and expression. A strategic contribution will be provided by SME in key technologies (virtual screening, detergent science, organic synthesis and biotech) and in exploitation, dissemination and resource acquisition skills. We will deliver crucial data for the development of new leads for health issues such as the design of new antibiotics or new strategies for theranostics and foster a synergistic approach to novel bioactive compounds development between academic and SME. The acquisition of new skill from staff will come from secondments aimed at training on research topics not available at the home institutions and attendance to courses, workshops, seminar and conferences. In an era where academic institutions are called to participate actively in technological and industrial development and SME provide services to and benefit of the wide breadth of academic research programs, we will foster a culture of synergistic exchange and cross-fertilization.
The consortium consists of 9 beneficiaries and 2 partners , of which 7 are academic and 4 are SME. During 4 years 16 ESRs, 6 ERs and 2 research managers will be seconded to 1 Institutions, where they will be supported by a team of leading scientists. The Network will promote the integration of academic and SME in combining excellent science with entrepreneurial approach and high-throughput methodologies.

Coordinator

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA

Address

Piazzale Aldo Moro 5
00185 Roma

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 128 800

Participants (8)

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UNIVERSIDADE NOVA DE LISBOA

Portugal

EU Contribution

€ 82 800

UNIVERSITA POLITECNICA DELLE MARCHE

Italy

EU Contribution

€ 82 800

INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA

Portugal

EU Contribution

€ 82 800

EXTREMOCHEM LDA

Portugal

EU Contribution

€ 50 600

CALIXAR

France

MOLIROM SRL

Italy

EU Contribution

€ 18 400

SAPIENZA INNOVAZIONE CONSORZIO

Italy

EU Contribution

€ 9 200

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Germany

EU Contribution

€ 9 200

Partners (2)

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NEW YORK STRUCTURAL BIOLOGY CENTER INC

THE CITY UNIVERSITY OF NEW YORK

Project information

Grant agreement ID: 823780

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2022

Funded under:

H2020-EU.1.3.3.

  • Overall budget:

    € 464 600

  • EU contribution

    € 464 600

Coordinated by:

UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA

Italy