An advanced cardiovascular regeneration approach
Each year cardiovascular disease causes over 1.8 million deaths in the EU alone. The EU-funded MechanoSignaling project will explore cardiovascular regeneration with the aim of re-establishing physiological tissue organisation for proper tissue functionality. Previous attempts to establish this organisation have been mainly based on trial-and-error. To achieve its goal, the project will perform quantitative in vitro experiments to inform novel multiscale computational models of Notch signalling and its consequences on regeneration. The aim is to obtain a mechanistic understanding of how critical pathways in the cardiovascular system (such as the Notch signalling pathway) drive the emergence of tissue organisation.
Fields of science
Funding SchemeERC-STG - Starting Grant
5612 AE Eindhoven
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