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Promoting patient safety by a novel combination of imaging technologies for biodegradable magnesium implants

Objective

Biomedical imaging has gained a significant technological push and is the mainstay for diag-nosis and therapy monitoring. Still, imaging is yet not optimized for the new class of biode-gradable Mg-based implants. MgSafe addresses this point by training 15 ESRs in both, imag-ing and implant technologies. All ESRs will develop their individual Personal Learning Envi-ronment (PLE) and be trained based on the “T-skills concept” in technologies and transferable skills relevant for their career development and prepared to take over leadership positions in an area of tremendous research promises and clinical relevance where the lack for experts is severe and very well recognized.
The ESRs will quantify the physical impact and suitability of a variety of modalities on Mg implants. Highly sophisticated imaging techniques (nano and µCT, MRT, PET, USPA, IR) will be developed beyond the forefront of medical device production in vivo and with in situ label-ling options to deliver non-invasively data on different time and length scales of the body reac-tion and material behavior during Mg degradation with a precision and plethora of details which is currently not available. Two Mg-alloys and CE-certified Mg-implants will be studied in rats and sheep. Dummy studies will be performed in parallel (following ASTM rules). The ob-tained multimodal imaging data will be combined with molecular biological/biochemical analy-sis, thereby increasing the information about physiological changes without using additional animals. An additional dimension will be added by the analysis of explants to obtain highest resolution chemical and material science data. All relevant biological and chemical in vivo and ex vivo data will be merged by computational 3D methods, simulations and machine learning approaches. The combination of these results will not only allow for an upscaling of the pro-cesses towards humans but will also deliver valuable data in terms of patient safety.

Field of science

  • /medical and health sciences/medical biotechnology/medical bioproducts/implants
  • /natural sciences/computer and information sciences/artificial intelligence/machine learning

Call for proposal

H2020-MSCA-ITN-2018
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

HELMHOLTZ-ZENTRUM GEESTHACHT ZENTRUM FUR MATERIAL- UND KUSTENFORSCHUNG GMBH
Address
Max Planck Strasse 1
21502 Geesthacht
Germany
Activity type
Research Organisations
EU contribution
€ 505 576,80

Participants (11)

CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 522 999,36
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
MEDIZINISCHE UNIVERSITAT GRAZ
Austria
EU contribution
€ 528 414,48
Address
Auenbruggerplatz 2
8036 Graz
Activity type
Higher or Secondary Education Establishments
UNIVERSITETET I OSLO
Norway
EU contribution
€ 292 342,32
Address
Problemveien 5-7
0313 Oslo
Activity type
Higher or Secondary Education Establishments
OSLOMET - STORBYUNIVERSITETET
Norway
EU contribution
€ 292 342,32
Address
Pilestredet 46
0167 Oslo
Activity type
Higher or Secondary Education Establishments
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 252 788,40
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
GOETEBORGS UNIVERSITET
Sweden
EU contribution
€ 281 982,96
Address
Vasaparken
405 30 Goeteborg
Activity type
Higher or Secondary Education Establishments
POLITECHNIKA WARSZAWSKA
Poland
EU contribution
€ 227 478,60
Address
Plac Politechniki 1
00 661 Warszawa
Activity type
Higher or Secondary Education Establishments
MRI. TOOLS GMBH
Germany
EU contribution
€ 252 788,40
Address
Robert Rossle Strasse 10
13125 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SYNTELLIX AG
Germany
EU contribution
€ 252 788,40
Address
Aegidientorplatz 2A
30159 Hannover
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SCANCO MEDICAL AG
Switzerland
EU contribution
€ 281 276,64
Address
Fabrikweg 2
8306 Bruettisellen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FUJIFILM SONOSITE BV
Netherlands
EU contribution
€ 265 619,88
Address
Joop Geesinkweg 140
1114 AB Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (1)

BRI.TECH GMBH
Austria
Address
Rossmanngasse 21/4
8010 Graz
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)