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Promoting patient safety by a novel combination of imaging technologies for biodegradable magnesium implants

Promoting patient safety by a novel combination of imaging technologies for biodegradable magnesium implants

Objective

Biomedical imaging has gained a significant technological push and is the mainstay for diag-nosis and therapy monitoring. Still, imaging is yet not optimized for the new class of biode-gradable Mg-based implants. MgSafe addresses this point by training 15 ESRs in both, imag-ing and implant technologies. All ESRs will develop their individual Personal Learning Envi-ronment (PLE) and be trained based on the “T-skills concept” in technologies and transferable skills relevant for their career development and prepared to take over leadership positions in an area of tremendous research promises and clinical relevance where the lack for experts is severe and very well recognized.
The ESRs will quantify the physical impact and suitability of a variety of modalities on Mg implants. Highly sophisticated imaging techniques (nano and µCT, MRT, PET, USPA, IR) will be developed beyond the forefront of medical device production in vivo and with in situ label-ling options to deliver non-invasively data on different time and length scales of the body reac-tion and material behavior during Mg degradation with a precision and plethora of details which is currently not available. Two Mg-alloys and CE-certified Mg-implants will be studied in rats and sheep. Dummy studies will be performed in parallel (following ASTM rules). The ob-tained multimodal imaging data will be combined with molecular biological/biochemical analy-sis, thereby increasing the information about physiological changes without using additional animals. An additional dimension will be added by the analysis of explants to obtain highest resolution chemical and material science data. All relevant biological and chemical in vivo and ex vivo data will be merged by computational 3D methods, simulations and machine learning approaches. The combination of these results will not only allow for an upscaling of the pro-cesses towards humans but will also deliver valuable data in terms of patient safety.
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Coordinator

HELMHOLTZ-ZENTRUM GEESTHACHT ZENTRUM FUR MATERIAL- UND KUSTENFORSCHUNG GMBH

Address

Max Planck Strasse 1
21502 Geesthacht

Germany

Activity type

Research Organisations

EU Contribution

€ 505 576,80

Participants (11)

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CONSIGLIO NAZIONALE DELLE RICERCHE

Italy

EU Contribution

€ 522 999,36

MEDIZINISCHE UNIVERSITAT GRAZ

Austria

EU Contribution

€ 528 414,48

UNIVERSITETET I OSLO

Norway

EU Contribution

€ 292 342,32

OSLOMET - STORBYUNIVERSITETET

Norway

EU Contribution

€ 292 342,32

MEDIZINISCHE HOCHSCHULE HANNOVER

Germany

EU Contribution

€ 252 788,40

GOETEBORGS UNIVERSITET

Sweden

EU Contribution

€ 281 982,96

POLITECHNIKA WARSZAWSKA

Poland

EU Contribution

€ 227 478,60

MRI. TOOLS GMBH

Germany

EU Contribution

€ 252 788,40

SYNTELLIX AG

Germany

EU Contribution

€ 252 788,40

SCANCO MEDICAL AG

Switzerland

EU Contribution

€ 281 276,64

FUJIFILM SONOSITE BV

Netherlands

EU Contribution

€ 265 619,88

Partners (1)

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BRI.TECH GMBH

Project information

Grant agreement ID: 811226

Status

Ongoing project

  • Start date

    1 October 2018

  • End date

    30 September 2022

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 3 956 398,56

  • EU contribution

    € 3 956 398,56

Coordinated by:

HELMHOLTZ-ZENTRUM GEESTHACHT ZENTRUM FUR MATERIAL- UND KUSTENFORSCHUNG GMBH

Germany