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Ultrasound Cavitation in Soft Materials

Ultrasound Cavitation in Soft Materials

Objective

The pressures and temperatures developing during the interactions of shockwaves with cavitation bubbles and soft matter induce complex phenomena, both at physical and biochemical levels. These have a non- exhaustive range of relevant applications including ultrasound-based therapies, surface cleaning and food processing. Our aim is to explore these processes both in micro and macroscales using experiments and to develop new computational capabilities for their simulations. Measurements will include temperature/ species forming in collapsing bubbles, identifying chemical reactions and possible tissue interaction, such as protein denaturation and agglomeration; tissue cavitation threshold and its control using nanoparticles, allowing development of new cavitation-mimicking-tissue materials extrapolating to actual tissue properties that will be used for in-vitro testing of equipment with minimum collateral damages. Computations will be based on advanced multi-resolution methods coupling fluid flow, chemical reactions and deforming material mechanics solvers, with physically consistent thermodynamic closure models for the involved materials; pressure wave propagation, bubble nucleation and material damage effects will link microscale phenomena to macroscale. Uncertainty quantification techniques will link computations with experimental data. UCOM builds upon the strong foundations of the PIs and their teams in training researchers in computational and experimental methods on cavitation and their strong record to successfully integrate research and technical applications. The final goal of the research and training program is to explore the enormous potential of the new and experimentally validated computational tools to guide breakthrough innovations and high-impact, high-tech technologies ranging across different sectors that all eventually enhance their careers and will be serving the well-being.

Coordinator

CITY UNIVERSITY OF LONDON

Address

Northampton Square
Ec1v 0hb London

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 909 517,68

Participants (7)

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TECHNISCHE UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 252 788,40

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Switzerland

EU Contribution

€ 562 553,28

SORBONNE UNIVERSITE

France

EU Contribution

€ 549 604,08

UNIVERSITEIT TWENTE

Netherlands

EU Contribution

€ 796 859,64

THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL

United Kingdom

EU Contribution

€ 606 345,12

OTTO-VON-GUERICKE-UNIVERSITAET MAGDEBURG

Germany

EU Contribution

€ 252 788,40

UNIVERSITE DE GENEVE

Switzerland

EU Contribution

€ 281 276,64

Partners (9)

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UNIVERSITY OF WASHINGTON

University of Michigan/Autophagy Journal

TSINGHUA UNIVERSITY

NATIONAL UNIVERSITY CORPORATION THEUNIVERSITY OF TOKYO

UNIVERSITE D'AVIGNON ET DES PAYS DE VAUCLUSE

KING'S COLLEGE LONDON

GUYS AND ST THOMAS' NHS FOUNDATIONTRUST

PRECISION ACOUSTICS LIMITED

DORNIER MEDTECH SYSTEMS GMBH

Project information

Grant agreement ID: 813766

Status

Ongoing project

  • Start date

    1 October 2018

  • End date

    30 September 2022

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 4 211 733,24

  • EU contribution

    € 4 211 733,24

Coordinated by:

CITY UNIVERSITY OF LONDON

United Kingdom