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Synthetic biology of carbohydrate-binding proteins: engineering protein-carbohydrate interactions for diagnostics and cell targeting

Objective

The aim of the Initial Training Network will be to train 15 early stage researchers in the emerging field of synthetic glycobiology, equipping them with the skills needed for future careers in the medical technologies sector.
Every living cell is covered in a coating of complex carbohydrates known as the glycocalyx. Anything that approaches the cell membrane must first descend through this forest of carbohydrates. Interactions between carbohydrates and lectins (carbohydrate-binding proteins) play essential roles in cell adhesion and endocytosis. Our growing understanding of glycoscience, and the advent of chemical and synthetic biology methodologies, presents an opportunity to redesign, synthesise and exploit glycocalyx and lectin components for diverse analytical, diagnostic and targeted therapeutic applications: this is the field of Synthetic Glycobiology.
The ESF-funded report, “A Roadmap for Glycosicence in Europe”, has highlighted the importance of glycoscience to the European bioeconomy. The European glycomics market is growing rapidly (>10% growth p.a.). There is an urgent need to train ESRs with the scientific and entrepreneurial skills required to enable European industry to exploit this rapidly growing market.
The synBIOcarb ETN brings together a diverse team of chemists, structural biologists, biophysicists, cell biologists and protein engineers who are pioneering the development of Synthetic Glycobiology, and four SMEs that are leading industrial innovation in glycoscience and protein engineering. Together, we will train 15 ESRs in the essential enabling technologies that underpin the development and exploitation of glycoscience: glycoconjugate synthesis; lectin engineering; biophysical interaction measurements; cell biology; analytical device technologies; entrepreneurial and transferable skills.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

UNIVERSITY OF LEEDS

Address

Woodhouse Lane
Ls2 9jt Leeds

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 909 517,68

Participants (7)

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ALBERT-LUDWIGS-UNIVERSITAET FREIBURG

Germany

EU Contribution

€ 505 576,80

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 549 604,08

KOBENHAVNS UNIVERSITET

Denmark

EU Contribution

€ 595 044

ACIB GmbH

Austria

EU Contribution

€ 528 414,48

CHEMICKY USTAV SLOVENSKEJ AKADEMIEVIED

Slovakia

EU Contribution

€ 466 493,76

GLYCODIAG

France

EU Contribution

€ 274 802,04

ENGENES BIOTECH GMBH

Austria

EU Contribution

€ 264 207,24

Partners (6)

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UNIVERSITE D'ORLEANS

France

KAROLINSKA INSTITUTET

Sweden

TECHNISCHE UNIVERSITAET GRAZ

Austria

UNIVERSITAET FUER BODENKULTUR WIEN

Austria

GLYCOSELECT LTD

Ireland

Elicityl SA

France

Project information

Grant agreement ID: 814029

Status

Ongoing project

  • Start date

    1 October 2018

  • End date

    30 September 2022

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 4 093 660,08

  • EU contribution

    € 4 093 660,08

Coordinated by:

UNIVERSITY OF LEEDS

United Kingdom