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Synthetic biology of carbohydrate-binding proteins: engineering protein-carbohydrate interactions for diagnostics and cell targeting

Objective

The aim of the Initial Training Network will be to train 15 early stage researchers in the emerging field of synthetic glycobiology, equipping them with the skills needed for future careers in the medical technologies sector.
Every living cell is covered in a coating of complex carbohydrates known as the glycocalyx. Anything that approaches the cell membrane must first descend through this forest of carbohydrates. Interactions between carbohydrates and lectins (carbohydrate-binding proteins) play essential roles in cell adhesion and endocytosis. Our growing understanding of glycoscience, and the advent of chemical and synthetic biology methodologies, presents an opportunity to redesign, synthesise and exploit glycocalyx and lectin components for diverse analytical, diagnostic and targeted therapeutic applications: this is the field of Synthetic Glycobiology.
The ESF-funded report, “A Roadmap for Glycosicence in Europe”, has highlighted the importance of glycoscience to the European bioeconomy. The European glycomics market is growing rapidly (>10% growth p.a.). There is an urgent need to train ESRs with the scientific and entrepreneurial skills required to enable European industry to exploit this rapidly growing market.
The synBIOcarb ETN brings together a diverse team of chemists, structural biologists, biophysicists, cell biologists and protein engineers who are pioneering the development of Synthetic Glycobiology, and four SMEs that are leading industrial innovation in glycoscience and protein engineering. Together, we will train 15 ESRs in the essential enabling technologies that underpin the development and exploitation of glycoscience: glycoconjugate synthesis; lectin engineering; biophysical interaction measurements; cell biology; analytical device technologies; entrepreneurial and transferable skills.

Field of science

  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /natural sciences/biological sciences/synthetic biology
  • /natural sciences/biological sciences/biochemistry/biomolecules/carbohydrates
  • /natural sciences/biological sciences/cell biology
  • /social sciences/economics and business/business and management/commerce

Call for proposal

H2020-MSCA-ITN-2018
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

UNIVERSITY OF LEEDS
Address
Woodhouse Lane
LS2 9JT Leeds
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 909 517,68

Participants (7)

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
EU contribution
€ 505 576,80
Address
Fahnenbergplatz
79098 Freiburg
Activity type
Higher or Secondary Education Establishments
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 549 604,08
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
KOBENHAVNS UNIVERSITET

Participation ended

Denmark
EU contribution
€ 595 044
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
ACIB GMBH
Austria
EU contribution
€ 528 414,48
Address
Krenngasse 37/2
8010 Graz
Activity type
Research Organisations
CHEMICKY USTAV SLOVENSKEJ AKADEMIEVIED
Slovakia
EU contribution
€ 466 493,76
Address
Dubravska Cesta 9
845 Bratislava
Activity type
Research Organisations
GLYCODIAG
France
EU contribution
€ 274 802,04
Address
520 Rue Du Chanteloup
45520 Chevilly
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ENGENES BIOTECH GMBH
Austria
EU contribution
€ 264 207,24
Address
Mooslackengasse 17
1190 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (6)

UNIVERSITE D'ORLEANS
France
Address
Chateau De La Source
45067 Orleans Cedex 2
Activity type
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Sweden
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
TECHNISCHE UNIVERSITAET GRAZ
Austria
Address
Rechbauerstrasse 12
8010 Graz
Activity type
Higher or Secondary Education Establishments
UNIVERSITAET FUER BODENKULTUR WIEN
Austria
Address
Gregor Mendel Strasse 33
1180 Wien
Activity type
Higher or Secondary Education Establishments
GLYCOSELECT LTD
Ireland
Address
24 Woodbine Park Blackrock
A94N447 Dublin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Elicityl SA
France
Address
746 Avenue Ambroise Croizat
38920 Crolles
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)