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Predictive Epigenetics: Fusing Theory and Experiment

Objective

Epigenetic mechanisms of gene regulation are profoundly implicated in human health and disease. However, we are still far from a complete mechanistic understanding of many epigenetic processes. Without an understanding of mechanisms we cannot fully understand function in healthy cells, in disease states, and the effects and side effects of therapeutic interventions. This severely limits the development of healthcare strategies. Research in epigenetics has typically been based on experiments and not on theory. Although this has delivered large amounts of information, information alone is not sufficient. Further progress urgently needs a paradigm shift in the way in which we study epigenetics, namely: epigenetics needs mathematics. Mathematical models are essential to capture and understand the complex, dynamic and stochastic nature of epigenetic regulation. Models are immensely powerful because they identify unifying concepts and enable predictions of system properties. Modelling epigenetic processes not only holds the key to a deep mechanistic understanding, but also ultimately, to drug response predictions, patient-specific diagnoses and new therapies. One of the greatest challenges to uniting biology and mathematics is the barrier between disciplines, because education in each field has traditionally been mono-disciplinary. The PEP-NET ITN will overcome these barriers by uniting 16 outstanding European academic laboratories and companies who have pioneered the successful combination of theoretical and experimental epigenetics. PEP-NET will train a new cohort of 15 European researchers to combine quantitative experiments with predictive theoretical models, and to apply this knowledge to basic and applied questions of epigenetic function.

Field of science

  • /natural sciences/mathematics/applied mathematics/mathematical model
  • /natural sciences/biological sciences/genetics and heredity/epigenetics

Call for proposal

H2020-MSCA-ITN-2018
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

HUMBOLDT-UNIVERSITAET ZU BERLIN
Address
Unter Den Linden 6
10117 Berlin
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 758 365,20

Participants (10)

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
Germany
EU contribution
€ 252 788,40
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Research Organisations
JOHN INNES CENTRE
United Kingdom
EU contribution
€ 303 172,56
Address
Norwich Research Park Colney
NR4 7UH Norwich
Activity type
Research Organisations
KOBENHAVNS UNIVERSITET
Denmark
EU contribution
€ 297 522
Address
Norregade 10
1165 Kobenhavn
Activity type
Higher or Secondary Education Establishments
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION
Switzerland
EU contribution
€ 281 276,64
Address
Maulbeerstrasse 66
4058 Basel
Activity type
Research Organisations
CENTRE EUROPEEN DE RECHERCHE EN BIOLOGIE ET MEDECINE
France
EU contribution
€ 274 802,04
Address
Rue Laurent Fries 1
67404 Illkirch Graffenstaden
Activity type
Research Organisations
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
Germany
EU contribution
€ 252 788,40
Address
Robert Rossle Strasse 10
13125 Berlin
Activity type
Research Organisations
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 606 345,12
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II
Italy
EU contribution
€ 261 499,68
Address
Corso Umberto I, 40
80138 Napoli
Activity type
Higher or Secondary Education Establishments
OSPEDALE SAN RAFFAELE SRL
Italy
EU contribution
€ 261 499,68
Address
Via Olgettina 60
20132 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DIAGENODE
Belgium
EU contribution
€ 512 640
Address
Rue Du Bois Saint Jean 3 Liege Park Science
4102 Seraing
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (5)

UNIVERSITY OF EAST ANGLIA
United Kingdom
Address
Earlham Road
NR4 7TJ Norwich
Activity type
Higher or Secondary Education Establishments
Oxford Nanoimaging Ltd
United Kingdom
Address
Wilkinson House, Jordan Hill
OX2 8DR Oxford
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Oxford Biodynamics Limited
United Kingdom
Address
9400 Garsington Road
OX4 2HN Oxford
Activity type
Other
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA CORP
United States
Address
3451 Walnut Street Room P 221
19104 Philadelphia
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF ADELAIDE
Australia
Address
North Terrace
5005 Adelaide
Activity type
Higher or Secondary Education Establishments