CORDIS
EU research results

CORDIS

English EN
Thrombo-inflammation in cardiovascular disease

Thrombo-inflammation in cardiovascular disease

Objective

The demographic change with aging populations places a heavy burden on health care systems worldwide. Despite all medical advances, age remains the major risk for cardiovascular disease (CVD), one of the top two killers. The aging vasculature provides an environment in which the finely tuned interplay between diverse cell types becomes disarrayed and thus fosters both, inflammation and thrombosis. For atherosclerosis and major vascular complications, i.e. myocardial infarction and stroke, inflammation and thrombosis are central pathological processes that have commonly been investigated independently, but now need integration within the new concept of 'vascular thrombo-inflammation'. Four beneficiaries have formed a strategic alliance to unravel the multifaceted mechanisms involved in thrombo-inflammation in the setting of CVD and identified interconnected research projects that benefit from the collaboration between outstanding centres in France, Germany and The Netherlands. Using unique and complementary advanced technologies, TICARDIO will dissect the mechanistic linkages between inflammation and thrombosis, investigate the multicellular interactions in the vasculature as drivers for thrombo-inflammation, and translate new concepts by multi-omics approaches into patient populations. The programme will train the next generation of basic and translational researchers by exposing them to a multidisciplinary research environment at major academic centres and a range of entrepreneurial and business settings at small and large pharmaceutical companies in Europe. The completion of an independent project in a research area with high unmet medical need will foster the development of creative, open minded and broadly knowledgeable biomedical researchers who are competitive for successful academic and company careers all over Europe. TICARDIO’s structures and interactions will serve as a blueprint for future training programmes in emerging fields of cardiovascular medicine.
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ

Address

Langenbeckstrasse 1
55131 Mainz

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 263 942

Participants (3)

Sort alphabetically

Sort by EU Contribution

Expand all

UNIVERSITEIT MAASTRICHT

Netherlands

EU Contribution

€ 1 328 099,40

UNIVERSITE D'AIX MARSEILLE

France

EU Contribution

€ 1 099 208,16

LEIBNIZ-INSTITUT FUR ANALYTISCHE WISSENSCHAFTEN-ISAS-EV

Germany

EU Contribution

€ 252 788,40

Partners (6)

Sort alphabetically

Expand all

BAYER AKTIENGESELLSCHAFT

TTOPSTART BV

Biocytex

2M ENGINEERING LIMITED

BOEHRINGER INGELHEIM PHARMA GMBH &CO KG

TRON - TRANSLATIONALE ONKOLOGIE ANDER UNIVERSITATSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAT MAINZ GEMEINNUTZIGE GMBH

Project information

Grant agreement ID: 813409

Status

Ongoing project

  • Start date

    1 April 2019

  • End date

    31 March 2023

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 3 944 037,96

  • EU contribution

    € 3 944 037,96

Coordinated by:

UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ

Germany