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BestTreat – Building a Gut Microbiome Engineering Toolbox for In-Situ Therapeutic Treatments for Non-alcoholic Fatty Liver Disease

Objective

BestTreat fosters education of ESRs in a project to uncover microbiome signatures for risk prediction and monitoring of NAFLD and to contribute to the development of therapeutic treatments based on metabolically beneficial microbial consortia. It trains 15 ESRs at world-leading academic institutions and companies, thus forming strong interdisciplinary links between industry, life and medical sciences, and end-users. BestTreat aims to train a new generation of highly qualified ESRs with entrepreneurial competencies in modern Life Sciences through state-of-the-art research projects. The projects focus on the identification and functional characterization of microbial consortia that contribute to metabolic control, and the application of this knowledge to develop novel leads for drug discovery and therapies for NAFLD. The new field on microbiome based therapeutics requires highly skilled scientists with interdisciplinary knowledge on medicine, systems biology and computer science, as well as hands-on experience with several types of tissue samples and model organisms that can optimally translate their research findings into sustainable improvements in clinical practice. BestTreat overcomes current barriers by establishing a strong, multidisciplinary and inter-sectoral training network, developing technologies tailored to solve key questions in human metabolism, microbiology and bioinformatics. The BestTreat programme will exploit recent developments in high-throughput and genome-wide screening technologies, combine these with modern molecular cell biology and systems biology approaches and ultimately translate the data into new leads for the discovery of live biotherapeutics. This specific cross-disciplinary training program will educate young scientists to the next level needed to advance this research field for the upcoming decennium. The training programme will be complemented with a complete set of transferable skills.

Field of science

  • /natural sciences/biological sciences/cell biology
  • /natural sciences/biological sciences/microbiology

Call for proposal

H2020-MSCA-ITN-2018
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT
Address
Beutenberg Strasse 11A
07745 Jena
Germany
Activity type
Research Organisations
EU contribution
€ 758 365,20

Participants (7)

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
Netherlands
EU contribution
€ 531 239,76
Address
Meibergdreef 15
1105AZ Amsterdam
Activity type
Higher or Secondary Education Establishments
ITA-SUOMEN YLIOPISTO
Finland
EU contribution
€ 842 417,28
Address
Yliopistonranta 1 E
70211 Kuopio
Activity type
Higher or Secondary Education Establishments
AFEKTA TECHNOLOGIES LTD
Finland
EU contribution
€ 280 805,76
Address
Jynkanniementie 30
71800 Siilinjarvi
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CHR. HANSEN A/S
Denmark
EU contribution
€ 297 522
Address
Boege Alle 10-12
2970 Hoersholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CLINICAL-MICROBIOMICS AS
Denmark
EU contribution
€ 297 522
Address
Ole Maaloes Vej 3
2200 Kobenhavn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DANMARKS TEKNISKE UNIVERSITET
Denmark
EU contribution
€ 595 044
Address
Anker Engelundsvej 1 Bygning 101 A
2800 Kgs Lyngby
Activity type
Higher or Secondary Education Establishments
RIJKSUNIVERSITEIT GRONINGEN
Netherlands
EU contribution
€ 531 239,76
Address
Broerstraat 5
9712CP Groningen
Activity type
Higher or Secondary Education Establishments

Partners (6)

FRIEDRICH-SCHILLER-UNIVERSITAT JENA
Germany
Address
Furstengraben 1
07743 Jena
Activity type
Higher or Secondary Education Establishments
SHANGHAI SIXTH PEOPLE'S HOSPITAL
China
Address
600 Yishan Road
200233 Shanghai
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
BRAVAD PRODUCTION APS
Denmark
Address
Radmandsgade 55
2200 Kobenhavn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GUBRA APS
Denmark
Address
Agern Alle 1
2970 Horsholm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UDATHA DASARADHI
Sweden
Address
Welhavens Gate 1B
0166 Oslo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIOFACTION KG
Austria
Address
Kundmanngasse 39/12
1030 Wien
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)