CORDIS
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CORDIS

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pH and Ion Transport in Pancreatic Cancer

Project information

Grant agreement ID: 813834

Status

Ongoing project

  • Start date

    1 November 2018

  • End date

    31 October 2022

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 4 027 619,16

  • EU contribution

    € 4 027 619,16

Coordinated by:

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Germany

Objective

pHioniC brings together highly synergistic expertise, research and training facilities to investigate pancreatic ductal adenocarcinoma (PDAC), a frequent and aggressive cancer that is still incurable. The programme’s central hypothesis has a strong grounding in the physiology of the exocrine pancreas. Secretion of the alkaline pancreatic juice, normally associated with digestion, leads to acidifications of the pancreas stroma resulting in an acid adaptation of pancreatic cells. We are first to propose that this adaptation facilitates PDAC initiation and progression by selecting for more aggressive phenotypes in interplay with PDAC driver mutations. pHioniC will:
(i) develop models (e.g. pancreas-/PDAC-specific pH-indicator mouse) to map the pH landscape in the normal and diseased pancreas,
(ii) characterize the impact of the acidic microenvironment in PDAC development and
(iii) design bespoke approaches to the treatment of PDAC that exploit the unique physiology of the pancreas and utilize a combination of nanocarrier and antibody technology for targeting.
Thereby, pHioniC provides an innovative interdisciplinary and intersectoral training for ESRs at the forefront of oncological research.
pHioniC comprises excellent complementary basic-research, clinical, and in silico laboratories that provided the seed discoveries for this novel concept, and industrial partners with a track record in therapeutic and diagnostic development in oncology. This highly synergistic team combines the state-of-the-art research tools and translational opportunities needed to meet the most ambitious doctoral programmes. pHioniC training for ESRs covers the fields of ion transport, oncology, imaging, bioinformatics and antibody technology, and is complemented by extensive transferable skills and personalised training elements. pHioniC will establish a lasting contribution towards European doctoral training beyond the lifetime of the project.

Coordinator

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Address

Schlossplatz 2
48149 Muenster

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 252 788,40

Participants (11)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 303 172,56

KOBENHAVNS UNIVERSITET

Denmark

EU Contribution

€ 892 566

UNIVERSITA DEGLI STUDI DI BARI ALDO MORO

Italy

EU Contribution

€ 261 499,68

UNIVERSITA DEGLI STUDI DI FIRENZE

Italy

EU Contribution

€ 261 499,68

UNIVERSITE DE LILLE

France

EU Contribution

€ 274 802,04

UNIVERSITE DE PICARDIE JULES VERNE

France

EU Contribution

€ 274 802,04

MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV

Germany

EU Contribution

€ 505 576,80

CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL

Germany

EU Contribution

€ 252 788,40

DEBRECENI EGYETEM

Hungary

EU Contribution

€ 229 715,28

PERCUROS BV

Netherlands

EU Contribution

€ 265 619,88

HEIDELBERG PHARMA RESEARCH GMBH

Germany

EU Contribution

€ 252 788,40

Partners (5)

TYPEONE S.R.L.

Italy

GEORG-AUGUST-UNIVERSITAT GOTTINGENSTIFTUNG OFFENTLICHEN RECHTS

Germany

UNIVERSITA DEGLI STUDI DI PADOVA

Italy

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

UNIVERSITA DEGLI STUDI DI TORINO

Italy

Project information

Grant agreement ID: 813834

Status

Ongoing project

  • Start date

    1 November 2018

  • End date

    31 October 2022

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 4 027 619,16

  • EU contribution

    € 4 027 619,16

Coordinated by:

WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER

Germany