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Leveraging room temperature diamond quantum dynamics to enable safe, first-of-its-kind, multimodal cardiac imaging

Objective

Cardiovascular Diseases (CVDs) are the number 1 cause of death globally: more people die annually from CVDs than from any other cause. Despite emerging diagnostics tools and therapeutics, several areas of significant unmet need remain unaddressed among CVD patients. The ability to personalize cardiovascular medical care and improve outcomes, will require characterization of disease processes at a molecular level. The current state-of-the-art, e.g., Positron emission tomography (PET), does not provide detailed information about the chemical state of the tissue at a molecular level, therefore it remains difficult to accurately diagnose and confidently select appropriate therapy in many circumstances. The MetaboliQs project brings together two areas of European excellence - diamond-based quantum sensing and medical imaging. We will translate a newly developed hyperpolarization method for magnetic resonance imaging (MRI) based on the quantum dynamics of nitrogen-vacancy (NV) centers. This breakthrough quantum technology will enable previously unachievable, highly sensitive quantification of metabolic activity, paving the way for precision diagnostics and better personalized treatment of cardiovascular and other metabolic diseases. For realizing and eventually commercializing the technology, MetaboliQs brings together a world-class multidisciplinary consortium with end to end expertise - leading diamond quantum technology research institutes (Fraunhofer IAF - quantum-grade diamond growth and fabrication, HUJI - quantum sensing) and innovative companies (Element 6 - worldwide leader in synthetic diamonds, NVision - inventor of diamond-based polarization), as well as two expert users of hyperpolarized and cardiovascular MRI (TUM, ETH Zurich - first in continental Europe to conduct clinical trials of hyperpolarized MRI for cardiovascular disease) and the market leader in electron paramagnetic resonance and preclinical MRI (Bruker).

Field of science

  • /engineering and technology/medical engineering/diagnostic imaging/magnetic resonance imaging
  • /medical and health sciences/clinical medicine/cardiology/cardiovascular diseases

Call for proposal

H2020-FETFLAG-2018-03
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Address
Hansastrasse 27C
80686 Munchen
Germany
Activity type
Research Organisations
EU contribution
€ 1 500 172,50

Participants (6)

NVISION IMAGING TECHNOLOGIES GMBH
Germany
EU contribution
€ 1 430 937,50
Address
Albert-einstein-allee
89081 Ulm
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Germany
EU contribution
€ 1 220 401,25
Address
Ismaninger Strasse 22
81675 Muenchen
Activity type
Higher or Secondary Education Establishments
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Switzerland
EU contribution
€ 936 812,50
Address
Raemistrasse 101
8092 Zuerich
Activity type
Higher or Secondary Education Establishments
BRUKER BIOSPIN GMBH
Germany
EU contribution
€ 228 800
Address
Am Silberstreifen
76287 Rheinstetten
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ELEMENT SIX (UK) LIMITED
United Kingdom
EU contribution
€ 960 290
Address
Global Innovation Centre Fermi Avenue
OX11 0QR Harwell Oxfordshire Didcot
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
THE HEBREW UNIVERSITY OF JERUSALEM
Israel
EU contribution
€ 390 387,50
Address
Edmond J Safra Campus Givat Ram
91904 Jerusalem
Activity type
Higher or Secondary Education Establishments