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Polymers in the Liver: Metabolism and Regulation

Polymers in the Liver: Metabolism and Regulation

Objective

Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational models fed with individual patient data, has the potential to provide the basis for a personalised diagnosis and treatment strategy. The PoLiMeR consortium (Polymers in the Liver: Metabolism and Regulation) has identified the inherited, liver-related diseases of glycogen and lipid metabolism as the ideal starting point for innovative research training in personalised ‘Systems Medicine’. Our perspective opens possibilities for the application of novel drugs and diagnostic tools to a range of both rare and frequent diseases.

To advance diagnostics and treatment of metabolic diseases beyond the state-of-the art, a new generation of scientists is needed. The complexity of the metabolic network and its aberrant behaviour in disease require experts with a deep knowledge and understanding of Systems Medicine approaches. The lack of truly interdisciplinary researchers, trained in the three ‘pillars of Systems Medicine’ - experimental, computational and clinical research - severely hampers progress in this field. PoLiMeR aims to fill this gap and brings together clinical, academic, and industrial experts on inherited metabolic diseases, computational modelling of the entire human metabolism, organ-on-chip technology, and detailed metabolic profiling. Our mission is to train our Early Stage Researchers (ESRs) to become dedicated Systems-Medicine experts, who can seamlessly collaborate between computational and wet-lab environments, and between clinical, academic, and industrial environments. This training will enable them to become the future leaders in the field and eventually make the difference for the patients.

Coordinator

ACADEMISCH ZIEKENHUIS GRONINGEN

Address

Hanzeplein 1
9713 Gz Groningen

Netherlands

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 929 669,58

Participants (11)

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HEINRICH-HEINE-UNIVERSITAET DUESSELDORF

Germany

EU Contribution

€ 505 576,80

CARL VON OSSIETZKY UNIVERSITAET OLDENBURG

Germany

EU Contribution

€ 126 394,20

UNIVERSITEIT LEIDEN

Netherlands

EU Contribution

€ 265 619,88

KUNGLIGA TEKNISKA HOEGSKOLAN

Sweden

EU Contribution

€ 281 982,96

JOHN INNES CENTRE

United Kingdom

EU Contribution

€ 303 172,56

UNIVERSITAETSKLINIKUM FREIBURG

Germany

EU Contribution

€ 252 788,40

UNIVERSITE DU LUXEMBOURG

Luxembourg

EU Contribution

€ 256 320

UNIVERSITETET I BERGEN

Norway

EU Contribution

€ 292 342,32

MIMETAS BV

Netherlands

EU Contribution

€ 265 619,88

ICENI DIAGNOSTICS LIMITED

United Kingdom

EU Contribution

€ 303 172,56

HITS GGMBH

Germany

EU Contribution

€ 252 788,40

Partners (4)

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UNIVERSITY OF EAST ANGLIA

SB Science Management UG

enerGQ BV

TM3 THERAPEUTICS BV

Project information

Grant agreement ID: 812616

Status

Ongoing project

  • Start date

    1 October 2018

  • End date

    30 September 2022

Funded under:

H2020-EU.1.3.1.

  • Overall budget:

    € 4 035 447,54

  • EU contribution

    € 4 035 447,54

Coordinated by:

ACADEMISCH ZIEKENHUIS GRONINGEN

Netherlands