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Deciphering the fungus-host-microbiota interplay to improve the management of fungal infections

Objective

Fungal infections have a major impact on human health, infecting about 2 billion people and killing more people each year than malaria or breast cancer. In particular, Candida species impose a high clinical and economic burden upon the European population. They frequently cause fatal hospital-acquired bloodstream infections. They also cause oral thrush and vaginitis. Most women have suffered an episode of vulvovaginal candidiasis, with ~8% enduring recurrent infections. The initiation and severity of a Candida infection depends on an intricate interplay between the infecting fungal strain and the individual’s immune status and microbiota, all of which can display significant variability. Therefore, for the first time, FunHoMic integrates experts in fungal pathogenesis, immunology, microbial ecology and ‘omics technologies to train 13 Early Stage Researchers (ESRs) who will define and exploit this Fungal-Host-Microbiota interplay to identify novel biomarkers (fungal or host genetic polymorphisms, microbiota profiles, metabolites or immune markers) for the stratification of a patient’s risk of serious fungal infection. This will pave the way for precision medicine in patient management through preventive or therapeutic interventions using antifungals, immune modulators or Live Biotherapeutic Products (LBPs). FunHoMic ESRs will gain broad interdisciplinary skills plus a translational mindset through our integrated, inter-sectoral training program. This will allow Europe to remain at the forefront of translational research in the field of medical mycology. To achieve this vision FunHoMic unites academic partners from France, Germany, The Netherlands, Switzerland, Spain and UK, a French Technology Research Institute with cutting-edge ‘omics technology platforms and three SMEs from The Netherlands, Belgium and France that bring unrivalled organ-on-chip and gastro-intestinal tract simulation technologies and expertise in the development and exploitation of innovative LBPs.

Field of science

  • /natural sciences/biological sciences/ecology
  • /medical and health sciences/health sciences/infectious disease/malaria
  • /natural sciences/biological sciences/microbiology/mycology
  • /medical and health sciences/basic medicine/immunology
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/oncology/cancer/breast cancer

Call for proposal

H2020-MSCA-ITN-2018
See other projects for this call

Funding Scheme

MSCA-ITN-ETN - European Training Networks

Coordinator

INSTITUT PASTEUR
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15
France
Activity type
Research Organisations
EU contribution
€ 549 604,08

Participants (9)

LEIBNIZ-INSTITUT FUR NATURSTOFF-FORSCHUNG UND INFEKTIONSBIOLOGIE EV HANS-KNOLL-ISTITUT
Germany
EU contribution
€ 505 576,80
Address
Beutenberg Strasse 11A
07745 Jena
Activity type
Research Organisations
STICHTING KATHOLIEKE UNIVERSITEIT
Netherlands
EU contribution
€ 265 619,88
Address
Geert Grooteplein Noord 9
6525 EZ Nijmegen
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT ZURICH
Switzerland
EU contribution
€ 281 276,64
Address
Ramistrasse 71
8006 Zurich
Activity type
Higher or Secondary Education Establishments
FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA
Spain
EU contribution
€ 250 904,88
Address
Passeig Vall D Hebron 119-129 Edificio De Recerca
08035 Barcelona
Activity type
Research Organisations
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
United Kingdom
EU contribution
€ 606 345,12
Address
King's College Regent Walk
AB24 3FX Aberdeen
Activity type
Higher or Secondary Education Establishments
BIOASTER FONDATION DE COOPERATION SCIENTIFIQUE
France
EU contribution
€ 274 802,04
Address
40 Avenue Tony Garnier
69007 Lyon
Activity type
Research Organisations
MIMETAS BV
Netherlands
EU contribution
€ 265 619,88
Address
Jh Oortweg 19
2333CH Leiden
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PRODIGEST
Belgium
EU contribution
€ 256 320
Address
Technologiepark 3
9052 Gent Zwijnaarde
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
BIOSE
France
EU contribution
€ 274 802,04
Address
Rue Des Freres Lumieres
15130 Arpajon Sur Cere
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)

Partners (5)

UNIVERSITE CLERMONT AUVERGNE
France
Address
49 Boulevard Francois Mitterrand
63000 Clermont-ferrand
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT GENT
Belgium
Address
Sint Pietersnieuwstraat 25
9000 Gent
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT LEIDEN
Netherlands
Address
Rapenburg 70
2311 EZ Leiden
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE PARIS
France
Address
85 Bd Saint Germain
75006 Paris
Activity type
Higher or Secondary Education Establishments
EVOTEC (UK) LIMITED
United Kingdom
Address
114 Innovation Drive, Milton Park Milton
OX14 4RZ Abingdon Oxfordshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)