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PRedictive In-silico Multiscale Analytics to support cancer personalized diaGnosis and prognosis, Empowered by imaging biomarkers

Objective

PRIMAGE proposes a cloud-based platform to support decision making in the clinical management of malignant solid tumours, offering predictive tools to assist diagnosis, prognosis, therapies choice and treatment follow up, based on the use of novel imaging biomarkers, in-silico tumour growth simulation, advanced visualisation of predictions with weighted confidence scores and machine-learning based translation of this knowledge into predictors for the most relevant, disease-specific, Clinical End Points.
PRIMAGE implements a hybrid cloud model, comprising the of use of open public cloud (based on EOSC services) and private clouds, enabling use by the scientific community (facilitating reuse of de-identified clinical curated data in Open Science) and also suitable for future commercial exploitation.
The proposed data infrastructures, imaging biomarkers and models for in-silico medicine research will be validated in the application context of two paediatric cancers, Neuroblastoma (NB, the most frequent solid cancer of early childhood) and the Diffuse Intrinsic Pontine Glioma (DIPG, the leading cause of brain tumour-related death in children). These two paediatric cancers are relevant validation cases given their representativeness of cancer disease, and their high societal impact, as they affect the most vulnerable and loved family members.
The European Society for Paediatric Oncology, two Imaging Biobanks and three of the most prominent European Paediatric oncology units are partners in this project, making retrospective clinical data (imaging, clinical, molecular and genetics) registries accessible to PRIMAGE, for training of machine learning algorithms and testing of the in-silico tools´ performance. Solutions to streamline and secure the data pseudonymisation, extraction, structuring, quality control and storage processes, will be implemented and validated also for use on prospective data, contributing European shared data infrastructures.

Call for proposal

H2020-SC1-DTH-2018-1
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Coordinator

FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA
Address
Av Fernando Abril Martorell 106
46026 Valencia
Spain
Activity type
Research Organisations
EU contribution
€ 1 389 692,50

Participants (16)

QUIBIM SOCIEDAD LIMITADA
Spain
EU contribution
€ 909 513,85
Address
Avenida De Aragon 30 Planta 13 Letra I
46021 Valencia
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MEDEXPRIM
France
EU contribution
€ 375 256,25
Address
815 La Pyreneenne
31670 Labege
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITAT KONSTANZ
Germany
EU contribution
€ 756 066,25
Address
Universitatsstrasse 10
78464 Konstanz
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DI PISA
Italy
EU contribution
€ 637 563,75
Address
Lungarno Pacinotti 43/44
56126 Pisa
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD DE ZARAGOZA
Spain
EU contribution
€ 796 183,75
Address
Calle Pedro Cerbuna 12
50009 Zaragoza
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF SHEFFIELD
United Kingdom
EU contribution
€ 616 680
Address
Firth Court Western Bank
S10 2TN Sheffield
Activity type
Higher or Secondary Education Establishments
ANSYS FRANCE SAS
France
EU contribution
€ 810 873,75
Address
Place Georges Pompidou 14-15
78180 Montigny Le Bretonneux
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
MATICAL INNOVATION SL
Spain
EU contribution
€ 325 756,44
Address
Avda Juan Carlos I 26 2C
45600 Talavera De La Reina Toledo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ST ANNA KINDERKREBSFORSCHUNG VEREIN

Participation ended

Austria
EU contribution
€ 0
Address
Zimmermannplatz 10
1090 Wien
Activity type
Research Organisations
KLINIKUM DER UNIVERSITAET ZU KOELN
Germany
EU contribution
€ 751 375
Address
Kerpener Strasse 62
50937 Koeln
Activity type
Higher or Secondary Education Establishments
SIOP EUROPE ASBL
Belgium
EU contribution
€ 323 364,38
Address
Avenue E Mounier 83
1200 Bruxelles
Activity type
Other
UNIVERSITAT POLITECNICA DE VALENCIA
Spain
EU contribution
€ 457 126,25
Address
Camino De Vera Sn Edificio 3A
46022 Valencia
Activity type
Higher or Secondary Education Establishments
AKADEMIA GORNICZO-HUTNICZA IM. STANISLAWA STASZICA W KRAKOWIE
Poland
EU contribution
€ 538 566,25
Address
Al Adama Mickiewicza 30
30-059 Krakow
Activity type
Higher or Secondary Education Establishments
CHEMOTARGETS S.L.
Spain
EU contribution
€ 661 326,25
Address
Doctor Aiguader 88
08003 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA
Italy
EU contribution
€ 192 314,33
Address
Via Zamboni 33
40126 Bologna
Activity type
Higher or Secondary Education Establishments
ST. ANNA KINDERKREBSFORSCHUNG GMBH
Austria
EU contribution
€ 770 261,25
Address
Zimmermannplatz 10
1090 Wien
Activity type
Research Organisations