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Single molecule bio-electronic smart system array for clinical testing

Single molecule bio-electronic smart system array for clinical testing

Objective

Digitizing biomarkers analysis by quantifying them at the single-molecule level is the new frontier for advancing the science of precision health. The SiMBiT project will develop a bio-electronic smart system leveraging on an existing lab-based proof-of-concept that can perform single-molecule detection of both proteins and DNA bio-markers. Specifically, the SiMBiT activities will develop the lab-based device into a cost-effective portable multiplexing array prototype that integrates, with a modular approach, novel materials and standard components/interfaces. The SiMBiT platform exhibits enhanced sensing capabilities: specificity towards both genomic and protein markers along with single-molecule detection limits and time-to-results within two hours. This makes the SiMBiT prototype the world best performing bio-electronic sensing system ever. SiMBiT will reach these ambitious goals with a multidisciplinary research effort involving device-physicists, analytical-chemists, bio-chemists, clinicians, electronic- and system-engineers. The platform is also single-use and cost-effective and can work in low-resource settings. The SiMBiT field-effect sensing system will be fabricated by means of future mass-manufacturable, large-area compatible, scalable techniques such as printing and other direct-writing processes. 3D printing of a module is also foreseen. The SiMBiT prototype will demonstrate, for first time, a matrix of up to 96 bio-electronic sensors and a Si IC chip for the processing of all data coming from the matrix, multiplexing single-molecule detection. As the Si IC pins are limited the chip area is reduced and its cost minimized, enabling a single-use assay plate. SiMBiT will apply the multiplexing single molecule technology to the early detection of human pancreatic neoplasms in a well-defined clinical context, performing simultaneous analysis of genomic and protein markers with a minimal sample volume, reduced costs and reduced time-to-results.
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Coordinator

CONSORZIO INTERUNIVERSITARIO PERLO SVILUPPO DEI SISTEMI A GRANDE INTERFASE

Address

Via Della Lastruccia 3
50019 Firenze

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 390 750

Participants (8)

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HEINRICH-HEINE-UNIVERSITAET DUESSELDORF

Germany

EU Contribution

€ 415 765

UNIVERSITA DEGLI STUDI DI BRESCIA

Italy

EU Contribution

€ 391 221,25

ABO AKADEMI

Finland

EU Contribution

€ 350 000

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

Italy

EU Contribution

€ 352 500

TECHNISCHE UNIVERSITEIT EINDHOVEN

Netherlands

EU Contribution

€ 389 998,75

FLEXENABLE LIMITED

United Kingdom

EU Contribution

€ 355 403,75

MASMEC SPA

Italy

EU Contribution

€ 262 500

EFFICIENT INNOVATION SAS

France

EU Contribution

€ 112 500

Project information

Grant agreement ID: 824946

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    30 June 2022

Funded under:

H2020-EU.2.1.1.

  • Overall budget:

    € 3 020 638,75

  • EU contribution

    € 3 020 638,75

Coordinated by:

CONSORZIO INTERUNIVERSITARIO PERLO SVILUPPO DEI SISTEMI A GRANDE INTERFASE

Italy