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Reshaping undesired Inflammation in challenged Tissue Homeostasis by Next-Generation regulatory T cell (Treg) Approaches – from Advanced Technology Developments to First-in-Human Trials

Project description

Advancing regulatory T-cell therapies

Immune-related diseases, such as autoimmunity and chronic inflammation, pose a significant socioeconomic burden. Treatment of these diseases usually involves immunosuppressive drugs, while regulatory T cells have also been proposed as a promising therapy. The EU-funded RESHAPE project aims to exploit the central role that regulatory T cells play in immune system homeostasis by suppressing excessive immune responses and maintaining peripheral tolerance. The key objective is to develop advanced regulatory T cell-based therapies and demonstrate their efficacy in restoring immunological balance following clinical adoptive transfer in patients with immunological disorders.

Call for proposal

H2020-SC1-BHC-2018-2020

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Sub call

H2020-SC1-2018-Single-Stage-RTD

Coordinator

CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Net EU contribution
€ 4 218 425,00
Address
Chariteplatz 1
10117 Berlin
Germany

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Region
Berlin Berlin Berlin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (9)

MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
Net EU contribution
€ 1 714 942,50
Address
Carl-neuberg-strasse 1
30625 Hannover

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Region
Niedersachsen Hannover Region Hannover
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES

Participation ended

France
Net EU contribution
€ 5 000,00
Address
Allee De L'ile Gloriette 5
44093 Nantes

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Region
Pays de la Loire Pays de la Loire Loire-Atlantique
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
Net EU contribution
€ 2 150 425,00
Address
Wellington Square University Offices
OX1 2JD Oxford

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Region
South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
NATURWISSENSCHAFTLICHES UND MEDIZINISCHES INSTITUT AN DER UNIVERSITAET TUEBINGEN
Germany
Net EU contribution
€ 521 375,00
Address
Markwiesenstrasse 55
72770 Reutlingen

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Region
Baden-Württemberg Tübingen Reutlingen
Activity type
Research Organisations
Non-EU contribution
€ 0,00
CELL THERAPY CATAPULT LIMITED
United Kingdom
Net EU contribution
€ 1 036 660,00
Address
12th Floor Tower Wing Guy's Hospital Great Maze Pond
SE1 9RT London

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
London Inner London — East Lewisham and Southwark
Activity type
Research Organisations
Non-EU contribution
€ 0,00
TISSUSE GMBH
Germany
Net EU contribution
€ 1 044 125,00
Address
Oudenarder Strasse 16
13347 Berlin

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Berlin Berlin Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
TXCELL

Participation ended

France
Net EU contribution
€ 0,00
Address
Les Cardoulines Allee De La Nertiere Sophia Antipolis
06560 Valbonne

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Alpes-Maritimes
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
INNOVATION ACTA S.R.L.
Italy
Net EU contribution
€ 426 100,00
Address
Via D.a. Azuni, 9
00196 Roma

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Centro (IT) Lazio Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
NANTES UNIVERSITE
France
Net EU contribution
€ 2 020 343,75
Address
1 Quai De Tourville
44000 Nantes

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Region
Pays de la Loire Pays de la Loire Loire-Atlantique
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00