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An integrative strategy of testing systems for identification of EDs related to metabolic disorders

Objective

Exposure to chemical substances that can produce endocrine disrupting effects represents one of the most critical public health threats nowadays. In line with the regulatory framework implemented within the European Union to reduce the levels of endocrine disruptors (EDs) for consumers, new and effective methods for ED testing are needed. The OBERON project will build an integrated testing strategy (ITS) to detect EDs-related metabolic disorders by developing, improving and validating a battery of test systems. It will be based on the concept of an integrated approach for testing and assessment (IATA). OBERON will combine 1) experimental methods (in vitro e.g. on 2D and 3D human-derived cells and tissues, and in vivo i.e. in zebrafish at different stages), 2) high throughput omics technologies, 3) epidemiology and human biomonitoring studies and 4) advanced computational models (in silico and systems biology) on functional endpoints related to metabolism. Such interdisciplinary framework will help at deciphering EDs based on mechanistic understanding of toxicity by providing and making available more effective alternative test methods relevant for human health that are in line with regulatory needs. Data generated in OBERON will also allow the development of novel Adverse Outcome Pathways (AOPs). The assays will be pre-validated in order to select the test systems that will show acceptable performance in terms of relevance for the second step of the validation process, i.e. the inter-laboratory validation as ring tests. Therefore, the aim of the OBERON project is to support the OECD conceptual framework for testing and assessment of EDs by developing specific assays not covered by the current tests, and to propose an IATA approach for ED-related metabolic disorders detection, which will be submitted to the JRC and OECD community.

Call for proposal

H2020-SC1-2018-Single-Stage-RTD
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Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 1 900 553,75

Participants (11)

INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS
France
EU contribution
€ 558 945
Address
Parc Technologique Alata
60550 Verneuil En Halatte
Activity type
Research Organisations
BIOFYZIKALNI USTAV AKADEMIE VED CESKE REPUBLIKY
Czechia
EU contribution
€ 215 250
Address
Kralovopolska 135
CZ-61265 Brno
Activity type
Research Organisations
UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
Spain
EU contribution
€ 259 706,25
Address
Avenida De La Universidad S-n
03202 Elche
Activity type
Higher or Secondary Education Establishments
ARISTOTELIO PANEPISTIMIO THESSALONIKIS
Greece
EU contribution
€ 793 725
Address
Kedea Building, Tritis Septemvriou, Aristotle Univ Campus
54636 Thessaloniki
Activity type
Higher or Secondary Education Establishments
FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA
Spain
EU contribution
€ 550 366,25
Address
C Rossello 132 Planta 05
08036 Barcelona
Activity type
Research Organisations
ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI
Italy
EU contribution
€ 304 000
Address
Via Mario Negri 2
20156 Milano
Activity type
Research Organisations
Masarykova univerzita
Czechia
EU contribution
€ 330 407,50
Address
Zerotinovo Namesti 9
601 77 Brno
Activity type
Higher or Secondary Education Establishments
METABOLON GMBH

Participation ended

Germany
EU contribution
€ 0
Address
Zeppelinstrasse 3
85399 Hallbergmoos
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
AGENCE NATIONALE DE LA SECURITE SANITAIRE DE L ALIMENTATION DE L ENVIRONNEMENT ET DU TRAVAIL
France
EU contribution
€ 76 058,75
Address
14 Rue Pierre Et Marie Curie
94700 Maisons Alfort
Activity type
Research Organisations
INSERM TRANSFERT SA
France
EU contribution
€ 379 750
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ENVE.X SINGLE MEMBER PC
Greece
EU contribution
€ 610 000
Address
Kosti Palama 11
551 33 Thesaloniki
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)