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An integrative strategy of testing systems for identification of EDs related to metabolic disorders

An integrative strategy of testing systems for identification of EDs related to metabolic disorders

Objective

Exposure to chemical substances that can produce endocrine disrupting effects represents one of the most critical public health threats nowadays. In line with the regulatory framework implemented within the European Union to reduce the levels of endocrine disruptors (EDs) for consumers, new and effective methods for ED testing are needed. The OBERON project will build an integrated testing strategy (ITS) to detect EDs-related metabolic disorders by developing, improving and validating a battery of test systems. It will be based on the concept of an integrated approach for testing and assessment (IATA). OBERON will combine 1) experimental methods (in vitro e.g. on 2D and 3D human-derived cells and tissues, and in vivo i.e. in zebrafish at different stages), 2) high throughput omics technologies, 3) epidemiology and human biomonitoring studies and 4) advanced computational models (in silico and systems biology) on functional endpoints related to metabolism. Such interdisciplinary framework will help at deciphering EDs based on mechanistic understanding of toxicity by providing and making available more effective alternative test methods relevant for human health that are in line with regulatory needs. Data generated in OBERON will also allow the development of novel Adverse Outcome Pathways (AOPs). The assays will be pre-validated in order to select the test systems that will show acceptable performance in terms of relevance for the second step of the validation process, i.e. the inter-laboratory validation as ring tests. Therefore, the aim of the OBERON project is to support the OECD conceptual framework for testing and assessment of EDs by developing specific assays not covered by the current tests, and to propose an IATA approach for ED-related metabolic disorders detection, which will be submitted to the JRC and OECD community.

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Address

Rue De Tolbiac 101
75654 Paris

France

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 900 553,75

Participants (10)

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INSTITUT NATIONAL DE L ENVIRONNEMENT ET DES RISQUES INERIS

France

EU Contribution

€ 558 945

BIOFYZIKALNI USTAV AKADEMIE VED CESKE REPUBLIKY

Czechia

EU Contribution

€ 215 250

UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE

Spain

EU Contribution

€ 259 706,25

ARISTOTELIO PANEPISTIMIO THESSALONIKIS

Greece

EU Contribution

€ 793 725

FUNDACION PRIVADA INSTITUTO DE SALUD GLOBAL BARCELONA

Spain

EU Contribution

€ 550 366,25

ISTITUTO DI RICERCHE FARMACOLOGICHE MARIO NEGRI

Italy

EU Contribution

€ 304 000

Masarykova univerzita

Czechia

EU Contribution

€ 330 407,50

METABOLOMIC DISCOVERIES GMBH

Germany

EU Contribution

€ 614 875

AGENCE NATIONALE DE LA SECURITE SANITAIRE DE L ALIMENTATION DE L ENVIRONNEMENT ET DU TRAVAIL

France

EU Contribution

€ 76 058,75

INSERM TRANSFERT SA

France

EU Contribution

€ 374 875

Project information

Grant agreement ID: 825712

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2023

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 6 745 894,50

  • EU contribution

    € 5 978 762,50

Coordinated by:

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France