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Novel Testing Strategies for Endocrine Disruptors in the Context of Developmental NeuroToxicity

Novel Testing Strategies for Endocrine Disruptors in the Context of Developmental NeuroToxicity

Objective

Clear evidence supports associations between endocrine disrupting chemical (EDC) exposure and impaired neurodevelopment. Yet, current hazard assessment of EDCs does not address developmental neurotoxicity. This is due to lack of scientific knowledge on how endocrine disruption is linked to developmental neurotoxicity (DNT). Thus there is an urgent need for novel testing and screening tools to address ED-induced DNT, based on new scientific knowledge. This calls for rapid advances in basic research as well as in the development of screening and testing tools close to the end-users. ENDpoiNTs will address this need by i) integrating advanced expertise in the EDC and DNT fields, two so far rather independent toxicology communities, and ii) continuous interaction with European and international key stakeholders. By combining state-of-the-art in silico and in vitro tools, innovative experimental designs and technologies, and advanced biostatistics on human epidemiological and biomonitoring data, ENDpoiNTs will 1) Generate the necessary scientific insights on the correlative and causal links between endocrine disruption and DNT; 2) Develop predictive in silico tools for chemical screening using machine learning and combination of evidence; 3) Develop and validate in vitro tools for chemical screening and testing that address sex- and species differences; 4) Develop novel molecular endpoints for existing animal-based test guidelines by integrating in vitro, in vivo, and human omics data with behavioural outcomes; 5) Ensure human relevance by linking experimental and epidemiological evidence; 6) Develop an integrated testing approach based on the developed in silico, in vitro, and in vivo assays and molecular markers; 7) Ensure regulatory relevance by developing strategies for implementation of these tools and endpoints into regulatory frameworks. In this way, ENDpoiNTs will meet the scientific, regulatory, and societal needs for improved hazard and risk assessment of EDCs

Coordinator

KAROLINSKA INSTITUTET

Address

Nobels Vag 5
17177 Stockholm

Sweden

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 280 178,75

Participants (15)

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STICHTING VU

Netherlands

EU Contribution

€ 926 776,25

BRUNEL UNIVERSITY LONDON

United Kingdom

EU Contribution

€ 112 500

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS

France

EU Contribution

€ 315 437,50

GREEN TOX GMBH

Switzerland

EU Contribution

€ 411 890

INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE

France

EU Contribution

€ 315 525

INSTITUT FUR UMWELTMEDIZINISCHE FORSCHUNG AN DER HEINRICH-HEINE-UNIVERSITAT DUSSELDORF GMBH

Germany

EU Contribution

€ 1 071 300

KARLSTADS UNIVERSITET

Sweden

EU Contribution

€ 101 677

UNIVERSITAT KONSTANZ

Germany

EU Contribution

€ 300 000

UNIVERSITEIT UTRECHT

Netherlands

EU Contribution

€ 632 133,75

UNIVERSITA DEGLI STUDI DI MILANO

Italy

EU Contribution

€ 898 517,50

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI

United States

EU Contribution

€ 124 972,50

THE UNIVERSITY OF QUEENSLAND

Australia

MURDOCH CHILDRENS RESEARCH INSTITUTE

Australia

UNIVERSIDAD COMPLUTENSE DE MADRID

Spain

EU Contribution

€ 199 375

UMEA UNIVERSITET

Sweden

EU Contribution

€ 198 750

Project information

Grant agreement ID: 825759

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2023

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 7 382 995

  • EU contribution

    € 6 889 033,25

Coordinated by:

KAROLINSKA INSTITUTET

Sweden