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Novel Testing Strategies for Endocrine Disruptors in the Context of Developmental NeuroToxicity

Objective

Clear evidence supports associations between endocrine disrupting chemical (EDC) exposure and impaired neurodevelopment. Yet, current hazard assessment of EDCs does not address developmental neurotoxicity. This is due to lack of scientific knowledge on how endocrine disruption is linked to developmental neurotoxicity (DNT). Thus there is an urgent need for novel testing and screening tools to address ED-induced DNT, based on new scientific knowledge. This calls for rapid advances in basic research as well as in the development of screening and testing tools close to the end-users. ENDpoiNTs will address this need by i) integrating advanced expertise in the EDC and DNT fields, two so far rather independent toxicology communities, and ii) continuous interaction with European and international key stakeholders. By combining state-of-the-art in silico and in vitro tools, innovative experimental designs and technologies, and advanced biostatistics on human epidemiological and biomonitoring data, ENDpoiNTs will 1) Generate the necessary scientific insights on the correlative and causal links between endocrine disruption and DNT; 2) Develop predictive in silico tools for chemical screening using machine learning and combination of evidence; 3) Develop and validate in vitro tools for chemical screening and testing that address sex- and species differences; 4) Develop novel molecular endpoints for existing animal-based test guidelines by integrating in vitro, in vivo, and human omics data with behavioural outcomes; 5) Ensure human relevance by linking experimental and epidemiological evidence; 6) Develop an integrated testing approach based on the developed in silico, in vitro, and in vivo assays and molecular markers; 7) Ensure regulatory relevance by developing strategies for implementation of these tools and endpoints into regulatory frameworks. In this way, ENDpoiNTs will meet the scientific, regulatory, and societal needs for improved hazard and risk assessment of EDCs

Field of science

  • /natural sciences/computer and information sciences/artificial intelligence/machine learning

Call for proposal

H2020-SC1-2018-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UPPSALA UNIVERSITET
Address
Von Kraemers Alle 4
751 05 Uppsala
Sweden
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 945 322,50

Participants (17)

STICHTING VU
Netherlands
EU contribution
€ 926 776,25
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
BRUNEL UNIVERSITY LONDON
United Kingdom
EU contribution
€ 112 500
Address
Kingston Lane
UB8 3PH Uxbridge
Activity type
Higher or Secondary Education Establishments
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 315 437,50
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
GREEN TOX GMBH
Switzerland
EU contribution
€ 411 890
Address
Langackerstrasse 49
8057 Zurich
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE
France
EU contribution
€ 315 525
Address
Boulevard De L'hopital 47
75013 Paris
Activity type
Research Organisations
INSTITUT FUR UMWELTMEDIZINISCHE FORSCHUNG AN DER HEINRICH-HEINE-UNIVERSITAT DUSSELDORF GMBH
Germany
EU contribution
€ 1 071 300
Address
Auf M Hennekamp 50
40225 Duesseldorf
Activity type
Other
KARLSTADS UNIVERSITET
Sweden
EU contribution
€ 101 677
Address
Universitetsgatan 2
651 88 Karlstad
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT KONSTANZ
Germany
EU contribution
€ 300 000
Address
Universitatsstrasse 10
78464 Konstanz
Activity type
Higher or Secondary Education Establishments
UNIVERSITEIT UTRECHT
Netherlands
EU contribution
€ 632 133,75
Address
Heidelberglaan 8
3584 CS Utrecht
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI MILANO
Italy
EU contribution
€ 898 517,50
Address
Via Festa Del Perdono 7
20122 Milano
Activity type
Higher or Secondary Education Establishments
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
United States
EU contribution
€ 124 972,50
Address
One Gustave L Levy Place Box 1075
10029 6574 New York
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF QUEENSLAND
Australia
EU contribution
€ 0
Address
St Lucia
4072 Brisbane
Activity type
Higher or Secondary Education Establishments
MURDOCH CHILDRENS RESEARCH INSTITUTE

Participation ended

Australia
EU contribution
€ 0
Address
Flemington Road Rch
3052 Parkville
Activity type
Research Organisations
UNIVERSIDAD COMPLUTENSE DE MADRID
Spain
EU contribution
€ 199 375
Address
Avenida De Seneca 2
28040 Madrid
Activity type
Higher or Secondary Education Establishments
UMEA UNIVERSITET
Sweden
EU contribution
€ 198 750
Address
Universitetomradet
901 87 Umea
Activity type
Higher or Secondary Education Establishments
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 334 856,25
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
UNIVERSITY OF MELBOURNE
Australia
EU contribution
€ 0
Address
Parkvilleoffice Of The Vice Chancellor
3010 Melbourne
Activity type
Higher or Secondary Education Establishments