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Green Enantioselective Halogenation for Drug Discovery and Manufacture

Green Enantioselective Halogenation for Drug Discovery and Manufacture

Objective

The aim of this project is to bring together subject matter experts from the academic and non-academic sectors to develop and exemplify the use of new catalysts and new green reactions to manufacture important halogenated compounds that could be used in drug discovery and drug production.
In order to achieve this objective the proposal brings together 3 partners with complementary skills:
University of Naples (UNINA): expertise in medicinal chemistry and drug discovery.
KelAda Pharmachem: expertise in green chemistry, chemical batch process development and scale-up.
UCO: expertise in process engineering of continuous flow processes.
We have broken this proposal into the following separate technical Work Packages:

WP1: Preparation of new catalysts for efficient desymmetrization [WP Leader: UNINA].

WP2: Development of enantiospecific halogenation including Fluorination. [WP Leader: Kelada Pharmachem].

WP3 Drug Candidate, library creation & in vitro testing. [WP Leader: Kelada Pharmachem]

WP4 Development of flow variant and scale-up.[WP Leader: UCO}

The above WP's will be undertaken via a series of interlinked secondment of researchers between the consortium partners and will be complemented by a series of training and other initiatives to facilitate interdisciplinary and inter-sectoral knowledge sharing and exchange.

Coordinator

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II

Address

Corso Umberto I, 40
80138 Napoli

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 110 400

Participants (2)

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KELADA PHARMACHEM LIMITED

Ireland

EU Contribution

€ 220 800

UNIVERSIDAD DE CORDOBA

Spain

EU Contribution

€ 276 000

Project information

Grant agreement ID: 823939

Status

Ongoing project

  • Start date

    1 April 2019

  • End date

    31 March 2023

Funded under:

H2020-EU.1.3.3.

  • Overall budget:

    € 607 200

  • EU contribution

    € 607 200

Coordinated by:

UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II

Italy