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Induced pluripotent stem cell seeded active osteochondral nanofibrous scaffolds

Project description

Novel biodegradable implants for older patients with osteochondral defects

The degeneration of cartilage in joints is associated with trauma or conditions such as osteoarthritis and rheumatic arthritis. To treat patients with these conditions, specific scaffolds are being developed for restorative procedures. The scaffolds should be biocompatible and biodegradable, able to control stem cell differentiation into osteoblasts via bioactive compounds, and they should also allow cell ingrowth from the adjacent tissues. Moreover, they should mimic the natural porous extracellular matrix of the tissue and form three-dimensional structures. Funded by the Marie Skłodowska-Curie Actions programme, the iP-OSTEO project aims to develop cell-based scaffolds for bone and cartilage repair in older patients with poor regenerative capacity. The proposed technology involves induced pluripotent stem cells with improved regeneration capacity and novel nanostructured scaffolds with a drug delivery system, stimulating cell regeneration.

Coordinator

USTAV EXPERIMENTALNI MEDICINY AKADEMIE VED CESKE REPUBLIKY VEREJNA VYZKUMNA INSTITUCE
Net EU contribution
€ 184 000,00
Address
Videnska 1083
14220 Praha 4
Czechia

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Region
Praha Hlavní město Praha
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Participants (13)

INOCURE SRO
Czechia
Net EU contribution
€ 193 200,00
Address
Politickych Veznu 935/13
11000 Praha

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Praha Hlavní město Praha
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
SZECHENYI ISTVAN EGYETEM
Hungary
Net EU contribution
€ 165 600,00
Address
Egyetem Ter 1
9026 Gyor

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Region
Dunántúl Nyugat-Dunántúl Győr-Moson-Sopron
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
OSPIN GMBH
Germany
Net EU contribution
€ 82 800,00
Address
Feurigstrasse 54
10827 Berlin

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Berlin Berlin Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
BIONEER A/S
Denmark
Net EU contribution
€ 9 200,00
Address
Kogle Alle 2
2970 Hoersholm

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Region
Danmark Hovedstaden Nordsjælland
Activity type
Research Organisations
Non-EU contribution
€ 0,00
ORTHOSERA GMBH
Austria
Net EU contribution
€ 46 000,00
Address
Dr. Karl-dorrek-strasse 23-29
3500 Krems An Der Donau

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Niederösterreich Waldviertel
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
UNIVERSITY COLLEGE LONDON
United Kingdom
Net EU contribution
€ 115 000,00
Address
Gower Street
WC1E 6BT London

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Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
HOCHSCHULE RHEIN-WAAL-HSRW RHINE-WAAL UNIVERSITY OF APPLIED SCIENCES
Germany
Net EU contribution
€ 55 200,00
Address
Marie Curie Strasse 1
47533 Kleve

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Region
Nordrhein-Westfalen Düsseldorf Kleve
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
LLS ROWIAK LASERLABSOLUTIONS GMBH
Germany
Net EU contribution
€ 18 400,00
Address
Garbsener Landstrasse 10
30419 Hannover

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Niedersachsen Hannover Region Hannover
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
CORTICALIS AS
Norway
Net EU contribution
€ 27 600,00
Address
Oslo Science Park, Gaustadalleen 21
0349 Oslo

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Norge Oslo og Viken Oslo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany
Net EU contribution
€ 27 600,00
Address
Hansastrasse 27c
80686 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Non-EU contribution
€ 0,00
BIOFABICS LDA
Portugal
Net EU contribution
€ 101 200,00
Address
Rua Alfredo Allen 455/461
4200-135 Porto

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Continente Norte Área Metropolitana do Porto
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
SCINUS HOLDING BV
Netherlands
Net EU contribution
€ 32 200,00
Address
Professor Bronkhorstlaan 10 G 48
3723 MB Bilthoven

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
West-Nederland Utrecht Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
INSTYTUT PODSTAWOWYCH PROBLEMOW TECHNIKI POLSKIEJ AKADEMII NAUK
Poland
Net EU contribution
€ 41 400,00
Address
Adolfa Pawinskiego 5b
02-106 Warsaw

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Region
Makroregion województwo mazowieckie Warszawski stołeczny Miasto Warszawa
Activity type
Research Organisations
Non-EU contribution
€ 0,00