CORDIS
EU research results

CORDIS

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Targeting genetic and epigenetic mechanisms in pediatric sarcomas.

Project information

Grant agreement ID: 805338

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2023

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 499 375

  • EU contribution

    € 1 499 375

Hosted by:

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

Germany

Project description

English EN

Genetic mechanisms in pathobiology of paediatric sarcomas

Current treatment of sarcomas, including paediatric sarcomas, has limited therapeutic options compared to other cancers. Therefore, generation of in vitro and in vivo models for sarcoma research is urgently needed for better understanding of the pathobiology of these tumours. Many types of soft tissue paediatric sarcomas have a similar underlying genetic mechanism, where chromosomal translocations generate fusion oncoproteins that serve as drivers of the disease. The EU-funded PedSarc project aims to take advantage of these genetic specifics of paediatric sarcomas to develop effective and specific therapies. Researchers will employ CRISPR/Cas9 and RNAi technologies to identify key players in epigenetic deregulation in paediatric sarcomas, and generate new mouse models to assist clinical translation and development of the new therapeutic targets for the diseases.

Host institution

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

Address

Im Neuenheimer Feld 280
69120 Heidelberg

Germany

Activity type

Research Organisations

EU Contribution

€ 1 499 375

Beneficiaries (1)

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

Germany

EU Contribution

€ 1 499 375

Project information

Grant agreement ID: 805338

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2023

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 499 375

  • EU contribution

    € 1 499 375

Hosted by:

DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG

Germany