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Noninvasive cell specific morphometry in neuroinflammation and degeneration

Project description

Novel markers for brain magnetic resonance imaging analysis

Mechanistic understanding of brain diseases and their treatment requires analysis of brain microstructural properties and their connection to brain functions. Magnetic resonance (MR) imaging research has established links between brain microstructure and inter-individual variations in brain functions, but this methodology's precision has been limited by the non-specificity of MR-derived markers. The EU-funded C-MORPH project aims to introduce ultra-high field MR imaging techniques to improve analysis resolution for future MR-based precision medicine applications. Project researchers will capitalise on their recent development of two spectroscopic MR methods: powder-averaged diffusion-weighted spectroscopy that can provide markers for cell specific structural degeneration, and spectrally tuned gradient trajectories that can isolate cell shape and size. C-MORPH aims to validate these experimental methods and adapt analyses to provide clinically applicable tools.

Field of science

  • /natural sciences/chemical sciences/analytical chemistry/spectroscopy

Call for proposal

ERC-2018-STG
See other projects for this call

Funding Scheme

ERC-STG - Starting Grant

Host institution

REGION HOVEDSTADEN
Address
Kongens Vaenge 2
3400 Hillerod
Denmark
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
EU contribution
€ 1 498 811

Beneficiaries (1)

REGION HOVEDSTADEN
Denmark
EU contribution
€ 1 498 811
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)