CORDIS
EU research results

CORDIS

English EN

DNA Damage Response-instructed Macrophage Differentiation in Granulomatous Diseases

Project information

Grant agreement ID: 805143

Status

Ongoing project

  • Start date

    1 April 2019

  • End date

    31 March 2024

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 500 000

  • EU contribution

    € 1 500 000

Hosted by:

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany

Project description

English EN

Localised chronic inflammation could shed light on shared mechanisms across many diseases

Chronic inflammation plays a role in numerous diseases and conditions, among them cancer, heart diseases, diabetes and rheumatoid arthritis. The processes underlying it are closely related to immune system function. Granulomatous diseases are also chronic inflammatory diseases. Although less well known, they affect millions, often young people. In these diseases, macrophages of the immune system run amok, leading to areas of organised inflammation called granulomas. It is known that macrophage precursors trigger the body's DNA damage response (DDR), leading to pathological changes in macrophages. The EU-funded DDRMac project is investigating the possibility that these changes are responsible for granuloma formation. Given the interlinked roles of inflammation, DDR, immune system dysfunction, and numerous diseases and conditions, the outcomes could have far-reaching therapeutic implications.

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Host institution

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Address

Chariteplatz 1
10117 Berlin

Germany

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 500 000

Beneficiaries (1)

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany

EU Contribution

€ 1 500 000

Project information

Grant agreement ID: 805143

Status

Ongoing project

  • Start date

    1 April 2019

  • End date

    31 March 2024

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 500 000

  • EU contribution

    € 1 500 000

Hosted by:

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Germany