3D thyroid gland models for screening endocrine disruptors
Three-dimensional (3D) cell assays more faithfully mimic the structure and function of native tissue, offering better test-models for biology, biochemistry and drug discovery studies. The EU-funded SCREENED project is working on native thyroid gland organoids, decellularised scaffolds or bioprinted constructs that house tissue-specific cells. Using these assays, researchers are investigating the effect of endocrine-disrupting chemicals on thyroid function offering a mechanistic understanding of their mode of action. Results will validate the sensitivity and specificity of these in vitro assays compared to existing 2D cell cultures and animal models.
Call for proposal
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Funding SchemeRIA - Research and Innovation action
V94 W5TV Limerick Clare
OX14 4RZ Abingdon Oxfordshire