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A multistage model of thyroid gland function for screening endocrine-disrupting chemicals in a biologically sex-specific manner

Project description

3D thyroid gland models for screening endocrine disruptors

Three-dimensional (3D) cell assays more faithfully mimic the structure and function of native tissue, offering better test-models for biology, biochemistry and drug discovery studies. The EU-funded SCREENED project is working on native thyroid gland organoids, decellularised scaffolds or bioprinted constructs that house tissue-specific cells. Using these assays, researchers are investigating the effect of endocrine-disrupting chemicals on thyroid function offering a mechanistic understanding of their mode of action. Results will validate the sensitivity and specificity of these in vitro assays compared to existing 2D cell cultures and animal models.

Call for proposal

H2020-SC1-2018-Single-Stage-RTD
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Coordinator

UNIVERSITEIT MAASTRICHT
Address
Minderbroedersberg 4
6200 MD Maastricht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 796 351,25

Participants (8)

UNIVERSITA DEGLI STUDI DI PARMA
Italy
EU contribution
€ 1 000 000
Address
Via Universita 12
43100 Parma
Activity type
Higher or Secondary Education Establishments
UNIVERSITE LIBRE DE BRUXELLES
Belgium
EU contribution
€ 499 200
Address
Avenue Franklin Roosevelt 50
1050 Bruxelles
Activity type
Higher or Secondary Education Establishments
CONSIGLIO NAZIONALE DELLE RICERCHE
Italy
EU contribution
€ 400 000
Address
Piazzale Aldo Moro 7
00185 Roma
Activity type
Research Organisations
PRESENS PRECISION SENSING GMBH
Germany
EU contribution
€ 493 750
Address
Am Biopark 11
93053 Regensburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN
Ireland
EU contribution
€ 101 555,86
Address
Belfield
4 Dublin
Activity type
Higher or Secondary Education Establishments
ATTUROS LIMITED
Ireland
EU contribution
€ 448 611,64
Address
Drumman East Williamston Whitegate
V94 W5TV Limerick Clare
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ARTTIC
France
EU contribution
€ 564 180
Address
Rue Du Dessous Des Berges 58A
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CYPROTEX DISCOVERY LIMITED
United Kingdom
EU contribution
€ 351 440
Address
114 Innovation Drive Milton Park
OX14 4RZ Abingdon Oxfordshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)