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Breaking down the wall between human health and environmental testing of endocrine disrupters: EndocRine Guideline Optimisation

Objective

ERGO presents a new approach that will support a paradigm shift in the regulatory use of standardized test guidelines (TGs) by breaking the existing wall between mammalian and non-mammalian vertebrate testing and assessment of endocrine disrupting chemicals (EDCs). The highly conserved thyroid system will be used as the “proof of concept”, but also other conserved endocrine axes/systems such as the Retinoid X Receptor (RXR) and the Hypothalamus Pituitary Gonadal (HPG) axis can be adapted to the cross-vertebrate class approach. ERGO will investigate a battery of draft in vitro assays and evaluate thyroid-responsive biomarkers and endpoints (B/E) suitable for extrapolation of effects from fish and amphibian tests to humans and other mammals (and vice versa) and finally validate successful B/E for inclusion in existing in vivo or new in vitro OECD TGs. A cross-class adverse outcome pathway (AOP) network will provide the scientifically plausible and evidence-based foundation for the selection of B/E in lower vertebrate assays predictive of human health outcomes. In silico modeling and biotransformation data will support cross-vertebrate class effect extrapolation. Major outcomes of ERGO will be: 1) New thyroid-related B/E for inclusion in OECD TGs for improved identification of TDC. 2) An Integrated Approach to Testing and Assessment (IATA) of chemicals for TD based on a multi-class vertebrate AOP network connecting endocrine mechanisms in one vertebrate class to adverse outcomes in another class for safer regulation of EDCs. 3) A tool for TG end users, such as regulators and industry, to extrapolate thyroid effects between vertebrate classes. Implementation of the ERGO IATA strategy in regulations of EDC will make hazard and risk assessment faster, cheaper, simpler and safer and support industry in the development of EDC-free products beneficial for environmental and human safety.

Field of science

  • /natural sciences/biological sciences/zoology/mammalogy

Call for proposal

H2020-SC1-2018-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

SYDDANSK UNIVERSITET
Address
Campusvej 55
5230 Odense M
Denmark
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 273 185

Participants (14)

UNIVERSITEIT ANTWERPEN
Belgium
EU contribution
€ 610 065
Address
Prinsstraat 13
2000 Antwerpen
Activity type
Higher or Secondary Education Establishments
AQUA TT UETP COMPANY LIMITED BY GUARANTEE
Ireland
EU contribution
€ 324 875
Address
Pleasants Street Olympic House
8 Dublin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany
EU contribution
€ 695 665
Address
Seminarstrasse 2
69117 Heidelberg
Activity type
Higher or Secondary Education Establishments
ECOLE NORMALE SUPERIEURE DE LYON
France
EU contribution
€ 534 875
Address
Parvis Rene Descartes 15
69342 Lyon
Activity type
Higher or Secondary Education Establishments
AARHUS UNIVERSITET
Denmark
EU contribution
€ 411 120
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
BASF SE
Germany
EU contribution
€ 85 312,50
Address
Carl Bosch Strasse 38
67063 Ludwigshafen Am Rhein
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UMWELTBUNDESAMT
Germany
EU contribution
€ 206 675
Address
Woerlitzer Platz 1
06844 Dessau-rosslau
Activity type
Research Organisations
Masarykova univerzita
Czechia
EU contribution
€ 417 875
Address
Zerotinovo Namesti 9
60177 Brno Stred
Activity type
Higher or Secondary Education Establishments
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 468 040
Address
Rue Michel Ange 3
75794 Paris
Activity type
Research Organisations
HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ
Germany
EU contribution
€ 450 000
Address
Permoserstrasse 15
04318 Leipzig
Activity type
Other
PETER MATTHIESSEN
United Kingdom
EU contribution
€ 104 249,91
Address
Dolfan Barn Beulah
LD5 4UE Llanwrtyd Wells
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
L'OREAL SA
France
EU contribution
€ 0
Address
14 Rue Royale
75008 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
FORSCHUNGSVERBUND BERLIN EV
Germany
EU contribution
€ 410 500
Address
Rudower Chaussee 17
12489 Berlin
Activity type
Research Organisations
PUBLIC UNIVERSITY CORPORATION YOKOHAMA CITY UNIVERSITY
Japan
EU contribution
€ 0
Address
22-2 Seto Kanazawa-ku
236 0027 Yokohama
Activity type
Higher or Secondary Education Establishments