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Integrated Implant Technology for Multi-modal Brain Interfaces

Project information

Grant agreement ID: 804005

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2023

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 496 000

  • EU contribution

    € 1 496 000

Hosted by:

THE UNIVERSITY OF SHEFFIELD

United Kingdom

Objective

Bioelectronic medicine may soon replace systemic drugs for treating some chronic conditions. The clinician will implant a miniature laboratory to deliver and coordinate a multi-modal treatment program directly at the affected tissue. The technology to bring this vision to the clinic is not yet available.

The IntegraBrain project will contribute by building an implantable network of sensors and actuators. Actuators will deploy electricity, light, drugs and thermal energy as modalities of the therapeutic program, while sensors will monitor its progress. A key technological advance will be a method for direct writing of the sensor-actuator network. To achieve this, we will develop a palette of functional inks where each ink supports one of the therapeutic modalities.

The technology has the potential to be tailored for applications in soft tissue organs, especially in the nervous system, where injury or degeneration can result in chronic disability. We will apply IntegraBrain technology in two niches of the nervous system in rodents. In the central nervous system, we will demonstrate seizure control by multi-modal neuromodulation. In the peripheral nervous system, we will demonstrate reversible block and excitation. For the first time, we will observe if multi-modal neuromodulation leads to synergistic effects on the nervous system.

With the IntegraBrain project, we hope to catalyse pre-clinical development of implantable human-machine interfaces for therapeutic applications.

Host institution

THE UNIVERSITY OF SHEFFIELD

Address

Firth Court Western Bank
S10 2tn Sheffield

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 400 375

Beneficiaries (2)

THE UNIVERSITY OF SHEFFIELD

United Kingdom

EU Contribution

€ 1 400 375

TECHNISCHE UNIVERSITAET DRESDEN

Germany

EU Contribution

€ 95 625

Project information

Grant agreement ID: 804005

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2023

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 1 496 000

  • EU contribution

    € 1 496 000

Hosted by:

THE UNIVERSITY OF SHEFFIELD

United Kingdom