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Modular cell factories for the production of 100 compounds from the shikimate pathway

Objective

Chemical synthesis is often difficult and may be subject to unclear mechanisms, frequently producing undesired by-products, while the complexity of some compounds may rendered them virtually unattainable. Nature can provide a wealth of products, however typically at very low concentrations, which makes their extraction process expensive. Conversely, microbial production is a well-established process for compounds naturally produced by the hosts or for which there are fully characterised biosynthetic pathways. However, relying on nature’s diversity as a provider for industrial applications typically requires major screenings for pathways, genes and optimisation of cell factories for the efficient production of the target compounds.
SHIKIFACTORY100 project aims towards the production of a universe of more than 100 high-added value compounds from the shikimate pathway, a hub in cell metabolism, through the development of an optimised shikimate chassis) and the proposal and implementation of novel biosynthetic routes exploring enzyme promiscuity to propose new pathways for the production of known and newly designed compounds. To champion SHIKIFACTORY100 project a consortium with some of the most relevant players in Europe has been assembled, covering research leading institutions in computational design, rapid prototyping and in vivo implementation of pathways and cell factories. As such, six world-leading research partners, four biotechnology SMEs with complementary focus areas and one large industrial company have been integrated. The research partners will be responsible for novel methods for pathway discovery and compound design, collaborating with the SMEs in the implementation and optimisation of the chassis, while SMEs and industrial partners will lead the assessment of the products and the exploitation of the results for different application areas. The industrial partner will be responsible for the validation of the production.

Coordinator

SILICOLIFE LDA

Address

Rua Do Canastreiro 15
4715 387 Braga

Portugal

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

EU Contribution

€ 1 091 125

Participants (10)

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ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE

Switzerland

EU Contribution

€ 700 838,75

DANMARKS TEKNISKE UNIVERSITET

Denmark

EU Contribution

€ 988 000

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 792 650

DSM FOOD SPECIALTIES BV

Netherlands

EU Contribution

€ 885 000

THE UNIVERSITY OF MANCHESTER

United Kingdom

EU Contribution

€ 1 030 016,25

UNIVERSIDADE DO MINHO

Portugal

EU Contribution

€ 351 122,50

UNIVERSIDADE NOVA DE LISBOA

Portugal

EU Contribution

€ 899 950

C-LECTA GMBH

Germany

EU Contribution

€ 400 900

GALCHIMIA SA

Spain

EU Contribution

€ 495 241,25

The National Non-Food Crops Centre

United Kingdom

EU Contribution

€ 360 500

Project information

Grant agreement ID: 814408

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    28 February 2023

Funded under:

H2020-EU.2.1.4.

  • Overall budget:

    € 7 995 343,75

  • EU contribution

    € 7 995 343,75

Coordinated by:

SILICOLIFE LDA

Portugal