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Active aGeIng and Osteoporosis: The next challenge for smarT nanobiOmaterials and 3D technologies

Active aGeIng and Osteoporosis: The next challenge for smarT nanobiOmaterials and 3D technologies

Objective

Osteoporosis is a systemic, degenerative disorder, predominantly affecting postmenopausal women (1 out of 3) but also men at an advanced age (1 out of 5) and it increases the prevalence of fracture risk. One fifth of people suffering an osteoporotic fracture will die within a year and half will become dependent. Appropriate anti-osteoporotic drugs are available but have serious side effects and they do not promote fracture healing.
The concept behind GIOTTO is to develop a platform of technologies and materials for the treatment of different types of osteoporotic fractures, designing, manufacturing and validating three different solutions:
1) 3D graded scaffold, which can be fixated with screws, to treat long bone fractures
2) Fibrous scaffold to deal with small, not confined pelvic fractures;
3) Radiopaque, bioresorbable, injectable cement to stabilise vertebral fractures.
The three devices will share smart nanobiomaterials that release chemical and biological cues to stimulate bone regeneration while reducing bone loss. Nanofunctionalisation and the smart, temporalised release of active molecules will allow for the systematic cell recruitment and activation needed to face the challenges of stimulating bone tissue regeneration in the elderly. The use of additive manufacturing technologies will enable device personalisation to match and better align with the patient’s anatomy and fracture type. A further boost to meet patient specificity and needs, will be provided through the use of functionalised magnetic nanoparticles in order to provide, via the application of an external oscillating magnetic field, a remote tool to activate mechanotransduction. In parallel, an Internet of Things platform will be developed to gather and collate measurable data inputs about device effectiveness and to provide decision support software as a service to improve the design, manufacture and clinical function of the proposed devices, ultimately managing the overall value chain.

Coordinator

POLITECNICO DI TORINO

Address

Corso Duca Degli Abruzzi 24
10129 Torino

Italy

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 920 750

Participants (13)

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UNIVERSITA DI PISA

Italy

EU Contribution

€ 332 000

UNIVERSITEIT MAASTRICHT

Netherlands

EU Contribution

€ 392 490

UNIVERSIDAD COMPLUTENSE DE MADRID

Spain

EU Contribution

€ 326 047,50

FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS

Greece

EU Contribution

€ 375 000

UNIVERSITY OF NEWCASTLE UPON TYNE

United Kingdom

EU Contribution

€ 362 445

DUBLIN CITY UNIVERSITY

Ireland

EU Contribution

€ 355 608,75

BEWARRANT

Belgium

EU Contribution

€ 324 625

CELLINK AB

Sweden

EU Contribution

€ 300 000

BIOMECH INNOVATIONS AG

Switzerland

EU Contribution

€ 622 067,50

FLUIDINOVA SA

Portugal

EU Contribution

€ 237 500

TECNOLOGIA NAVARRA DE NANOPRODUCTOS SL

Spain

EU Contribution

€ 263 500

NOVAICOS SRLS

Italy

EU Contribution

€ 550 312,50

YODIWO ANONYMI ETAIREIA SCHEDIASISOLOKLIROMENON KYKLOMATON

Greece

EU Contribution

€ 297 750

Project information

Grant agreement ID: 814410

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    28 February 2023

Funded under:

H2020-EU.2.1.3.

H2020-EU.2.1.2.

  • Overall budget:

    € 5 660 096,25

  • EU contribution

    € 5 660 096,25

Coordinated by:

POLITECNICO DI TORINO

Italy