Investigating Mechanisms and Models Predictive of Accessibility of Therapeutics (IM2PACT) Into The Brain
Objective
1.Identification and validation of specific genes and/or mechanisms which are altered in brain endothelial cells in disease.
2. Generation, validation and characterisation of robust and predictive iPSC-derived BBB models: The developed models should be more reflective of the in vivo situation than existing models, in the healthy and disease states.
3. New, efficacious and safe mechanisms and technologies of brain delivery: The output of this topic should also result in an expanded and deepened understanding of the fundamental processes that underpin drug-trafficking across the BBB, which in turn can further support endeavours to elucidate novel and more efficacious brain delivery mechanisms.
4. Characterised new genetic models for the diseases of interest in this topic which are better amenable to evaluate disease-modifying agents.
5. Characterised mechanisms of neurotropic virus-mediated BBB and CNS penetration for development of selective brain delivery systems.
6. Established in silico/mathematical models in predicting BBB penetration of therapeutics (such as receptor-or carrier-mediated transcytosis for delivery across the BBB) and pharmacokinetics of biopharmaceutics in different compartments of CNS.
7. Identification of relevant translational readouts which are better amenable to elucidate the role of the BBB in the pathogenesis of neurodegeneration and could eventually lead to new targets for the treatment of the neurovascular causes of the diseases.
Funding Scheme
IMI2-RIA - Research and Innovation action
Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
Address
Wellington Square University Offices
Ox1 2jd Oxford
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU Contribution
€ 2 462 486,25
Participants (26)
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UPPSALA UNIVERSITET
Sweden
EU Contribution
€ 1 113 250
STICHTING VUMC
Netherlands
EU Contribution
€ 290 437,50
UNIVERSITY OF DUNDEE
United Kingdom
EU Contribution
€ 354 008,75
ACADEMISCH ZIEKENHUIS LEIDEN
Netherlands
EU Contribution
€ 297 500
KOBENHAVNS UNIVERSITET
Denmark
EU Contribution
€ 532 198,75
AARHUS UNIVERSITET
Denmark
EU Contribution
€ 483 966,25
UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Germany
EU Contribution
€ 288 661,25
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany
EU Contribution
€ 290 187,50
AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH
Austria
EU Contribution
€ 582 292,50
MIMETAS BV
Netherlands
EU Contribution
€ 251 812,50
THE OPEN UNIVERSITY
United Kingdom
EU Contribution
€ 232 283,75
UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT
Germany
EU Contribution
€ 213 718,75
STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER
Germany
EU Contribution
€ 290 312,50
ARTEMIS BIO-SUPPORT B.V.
Netherlands
EU Contribution
€ 290 380
NEUWAY PHARMA GMBH
Germany
EU Contribution
€ 112 500
THE UNIVERSITY OF SHEFFIELD
United Kingdom
EU Contribution
€ 249 305
UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA
Italy
EU Contribution
€ 67 565
PHARMACOIDEA FEJLESZTO ES SZOLGALTATO KFT
Hungary
EU Contribution
€ 300 058,75
CARDIFF UNIVERSITY
United Kingdom
EU Contribution
€ 297 075
SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT
France
PFIZER LIMITED
United Kingdom
NOVARTIS PHARMA AG
Switzerland
NOVO NORDISK A/S
Denmark
FUJIFILM CELLULAR DYNAMICS INC
United States
JANSSEN PHARMACEUTICA NV
Belgium
H. LUNDBECK AS
Denmark
Project information
IM2PACT
Grant agreement ID: 807015
Status
Ongoing project
-
Start date
1 January 2019
-
End date
31 December 2023
Funded under:
H2020-EU.3.1.7.
-
Overall budget:
€ 17 410 136
-
EU contribution
€ 9 000 000
Project information
IM2PACT
Grant agreement ID: 807015
Status
Ongoing project
-
Start date
1 January 2019
-
End date
31 December 2023
Funded under:
H2020-EU.3.1.7.
-
Overall budget:
€ 17 410 136
-
EU contribution
€ 9 000 000
Deliverables
Deliverables not available
Publications
Publications not available
Project information
IM2PACT
Grant agreement ID: 807015
Status
Ongoing project
-
Start date
1 January 2019
-
End date
31 December 2023
Funded under:
H2020-EU.3.1.7.
-
Overall budget:
€ 17 410 136
-
EU contribution
€ 9 000 000
Project information
IM2PACT
Grant agreement ID: 807015
Status
Ongoing project
-
Start date
1 January 2019
-
End date
31 December 2023
Funded under:
H2020-EU.3.1.7.
-
Overall budget:
€ 17 410 136
-
EU contribution
€ 9 000 000
