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EVPRO - Development of Extracellular Vesicles loaded hydrogel coatings with immunomodulatory activity for Promoted Regenerative Osseointegration of revision endoprosthesis

EVPRO - Development of Extracellular Vesicles loaded hydrogel coatings with immunomodulatory activity for Promoted Regenerative Osseointegration of revision endoprosthesis

Objective

Revision endoprosthesis are mostly associated with post-surgical physical symptoms that can lead to long-term confinement to bed and in severe cases to implant rejection. Severe inflammatory reactions in the endoprosthesis shaft can occur due to a previous long-term prosthesis. Medically managing the inflammation process is challenging as it is difficult to introduce drugs to the site of inflammation after implantation of the revision endoprosthesis. EVPRO overcomes this problem by using human mesenchymal stem cell derived extracellular vesicles (MSC-EVs) which are known to suppress inflammatory reaction in humans, exert pro-regenerative effects in osteogenic setting and successfully treat patients with steroid-refractory graft-versus-host disease. In this project the MSC-EVs will be applied in direct physical proximity to the site of inflammation and will therefore affix on the implant surface to deliver their anti-inflammatory and regenerative effect in response to the local inflammation status. This will be achieved by safe integration of the MSC-EVs in a smart biodegradable hydrogel that is absorbed into the micropores of a TiO2 coating on the surface of conventional titan endoprosthesis. EVPRO enables the progression of each individual technology, along with EVPRO system level integration developments, into pre-clinical trials, this means in detail, the development of a GMP conformed large scale production of MSC-EVs, the establishing of an uniform method to purify and select the most potential MSC-EVs with a microfluidic system and the design of a self-regulated hydrogel as protection matrix of MSC-EVs with the function to store and release MSC-EVs in response to the inflammation status,
The EVPRO project is an integration of multidisciplinary post-proof of concept technologies which enables the successful resolution of the enhanced osseointegration of endoprosthesis for osteoarticular tissue regeneration.
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Coordinator

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Address

Hansastrasse 27c
80686 Munchen

Germany

Activity type

Research Organisations

EU Contribution

€ 865 646,25

Participants (10)

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UNIVERSITAETSKLINIKUM ESSEN

Germany

EU Contribution

€ 603 250

LONZA NETHERLANDS BV

Netherlands

EU Contribution

€ 411 975

DUBLIN CITY UNIVERSITY

Ireland

EU Contribution

€ 569 070

THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

Ireland

EU Contribution

€ 438 327,50

DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV

Germany

EU Contribution

€ 526 080

UNIVERSITEIT MAASTRICHT

Netherlands

EU Contribution

€ 509 363,75

MEOTEC GMBH & CO KG

Germany

EU Contribution

€ 511 250

STRYKER EUROPEAN OPERATIONS BV

Netherlands

EU Contribution

€ 393 750

POLITECNICO DI TORINO

Italy

EU Contribution

€ 500 000

UNIVERSITAETSKLINIKUM KNAPPSCHAFTSKRANKENHAUS BOCHUM GMBH

Germany

EU Contribution

€ 470 376,25

Project information

Grant agreement ID: 814495

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2022

Funded under:

H2020-EU.2.1.3.

H2020-EU.2.1.2.

  • Overall budget:

    € 5 799 088,75

  • EU contribution

    € 5 799 088,75

Coordinated by:

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.

Germany