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User-centred smart nanobiomaterial-based 3D matrices for chondral repair

Objective

The RESTORE project aims at developing an effective approach to manage the specific unmet clinical needs to treat knee chondral lesions. RESTORE, built upon the consortium’s proofs-of-concept and discussions between orthopaedic surgeons, tissue engineers, material scientists, cell biologists and SMEs, will realize a new generation of smart nanoenabled 3D matrices able to fit into complex lesion geometry, modulate undesirable biological events, and remotely control, stimulate and monitor cartilage repair. To create smart and functional 3D matrices, RESTORE will develop (i) nanobiomaterial-based nanocarriers to modulate inflammatory, cartilage extracellular matrix degradation and infection threats, (ii) stimuli-responsive nanobiomaterials tuned via external physical stimulus using radiofrequency and electromagnetic fields, and (iii) non-invasive wearable and wireless device for remote stimulus and regeneration monitoring. The nanobiomaterials will be integrated into cutting-edge 3D matrices that meet the needs of severe and mild chondral lesions: 1) the COPLA Scaffold commercialised since 2017 for animal health use and 2) 3D cartilage microtissues engineered via 3D bioprinting of iPS cells in a nanocellulose and alginate bioink. The technology development in RESTORE will reach TRL5 and enable substantial clinical advances in regenerative medicine. Untreated or not-correctly treated chondral lesions are likely to progress towards osteoarthritis (OA), which affects 242 million people globally (costs/patient/year: 10,452€). RESTORE will address the shortfalls of current therapeutic solutions while aiming to reduce the overall burden of OA. RESTORE’s outcomes hold high exploitation and commercial potential to boost the competitiveness of European companies, striving to diminish or delay the onset of OA, reducing hospitalization, number of surgeon interventions and time off work, thus leading to more cost-efficient health care and promote wellbeing and active ageing.
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Coordinator

INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA

Address

Rua Alfredo Allen 208
4200 135 Porto

Portugal

Activity type

Research Organisations

EU Contribution

€ 933 243,45

Participants (9)

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OULUN YLIOPISTO

Finland

EU Contribution

€ 918 802,80

UNIVERSITAET ULM

Germany

EU Contribution

€ 409 312,50

HASKOLINN I REYKJAVIK EHF

Iceland

EU Contribution

€ 318 185

FUNDACION CIDETEC

Spain

EU Contribution

€ 554 375

GOETEBORGS UNIVERSITET

Sweden

EU Contribution

€ 553 050

SINTEF AS

Norway

EU Contribution

€ 699 705

UNIVERSITA DEGLI STUDI DEL PIEMONTE ORIENTALE AMEDEO AVOGADRO

Italy

EU Contribution

€ 449 937,50

ASKEL HEALTHCARE OY

Finland

EU Contribution

€ 303 750

3DTECH OY

Finland

EU Contribution

€ 399 375

Project information

Grant agreement ID: 814558

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 August 2022

Funded under:

H2020-EU.2.1.3.

H2020-EU.2.1.2.

  • Overall budget:

    € 5 539 736,25

  • EU contribution

    € 5 539 736,25

Coordinated by:

INEB-INSTITUTO NACIONAL DE ENGENHARIA BIOMEDICA

Portugal