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Synthetic microbial consortia-based platform for flavonoids production using synthetic biology

Synthetic microbial consortia-based platform for flavonoids production using synthetic biology

Objective

This Project pursues the implementation a standardized pipeline for surrogate production of plant flavonoids in synthetic microbial consortia (SMCs) by means of standardization and systems-guided assembly of highly complex biological devices. Flavonoids are the more abundant and consumed group of phytonutrients, used in numerous applications including functional food & beverages, dietary supplements, cosmetics, and pharmaceuticals. Despite its growing demand, flavonoids production remains elusive to chemical synthesis and biotech-based approaches, thus current flavonoid market is constrained to the scarce plant-based sources. These compounds are synthetized in nature through complex pathways involving an intense chemicals trafficking through plant compartments. By facilitating component troubleshooting and re-usability—instead of optimizing a single whole-cell biocatalyst— SynBio4Flav will recreate such non-homogeneous scenario by breaking-down specific portions of the complexes and highly regulated biochemical routes between different microbial species, each of them genetically programmed to deliver an optimal output of the corresponding biosynthetic step(s) i.e. through a distributed catalysis engineered in a defined SMC. Enabling such novel approach, SynBio4Flav will push the existing boundaries of the synthetic biology by acting along the whole Synthetic Biology hierarchy abstraction, and remarkably, in those with high complexity level e.g. cell systems and microbial communities. By creating libraries of optimized cell systems programmed to deliver an optimal output, and novel synthetic biology tools for cell systems assembling into 3D SMCs, SysBio4Flav will reach a TRL5 in production of natural and new-to-nature glycosylated flavonoids. The durable output of SynBio4Flav will be a standardized platform containing hundreds of optimal cell systems for exploring the full combinatorial space of flavonoids biosynthesis, including thousands of new-to-nature analogues.
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Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Address

Calle Serrano 117
28006 Madrid

Spain

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 704 071,25

Participants (10)

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CHALMERS TEKNISKA HOEGSKOLA AB

Sweden

EU Contribution

€ 1 206 128,75

DEUTSCHES INSTITUT FUER ERNAEHRUNGSFORSCHUNG POTSDAM REHBRUECKE

Germany

EU Contribution

€ 552 987,50

UNIWERSYTET PRZYRODNICZY WE WROCLAWIU

Poland

EU Contribution

€ 528 110

UNIVERSITAET GREIFSWALD

Germany

EU Contribution

€ 706 250

UNIVERSIDAD DE OVIEDO

Spain

EU Contribution

€ 628 985

EXTRASYNTHESE SAS

France

EU Contribution

€ 270 208,75

BIOPOLIS SL

Spain

EU Contribution

€ 614 752,50

EXPLORA SRL

Italy

EU Contribution

€ 566 666,25

SYMRISE AG

Germany

EU Contribution

€ 268 512,50

LIQUIFER SYSTEMS GROUP GMBH

Austria

EU Contribution

€ 324 378,75

Project information

Grant agreement ID: 814650

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    28 February 2023

Funded under:

H2020-EU.2.1.4.

  • Overall budget:

    € 7 371 051,25

  • EU contribution

    € 7 371 051,25

Coordinated by:

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain